Tyrosine Kinase Inhibitors In Metastatic Non Small Cell Lung Cancer

Status Active, not recruiting

Clinical Trial Summary

Aim of the present retrospective study is to evaluate molecular factors of primary resistance to tyrosine kinase inhibitors in metastatic non small cell lung cancer (NSCLC) patients. The investigators assess first, the incidence of epidermal growth factor receptor (EGFR) and Kirsten ras sarcoma viral oncogene homolog (KRAS) mutations, SOS and hepatocyte growth factor (HGF) expression, anaplastic lymphoma kinase (ALK) translocation and expression and, secondly, the investigators correlate molecular markers with clinical features and outcome in terms of response rate, progression free survival and overall survival.

Clinical Trial Description

Non small cell lung cancer patients. ;

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01163058
Study type	Observational
Source	Istituto Clinico Humanitas
Contact
Status	Active, not recruiting
Phase	N/A
Start date	June 2010
Completion date	July 2011

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