Non Small Cell Lung Cancer Clinical Trial
Official title:
A Phase 2, Open-label Study of IMC-1121B in Combination With Paclitaxel and Carboplatin as First-line Therapy in Patients With Stage IIIB/IV Non-small Cell Lung Cancer
The purpose of this study is to evaluate the progression-free survival (PFS) rate at 6 months of ramucirumab administered in combination with paclitaxel and carboplatin as first-line therapy for Stage IIIB or IV non-small cell lung cancer
Non-small cell lung cancer (NSCLC) accounts for 75-80% of all lung cancers. The advanced
stages are associated with poor survival rates, a median survival rate of approximately 3.9
months if left untreated.
Angiogenesis is a process for wound healing and restoring blood flow to tissues after
injury. It is the physiological process involving the growth of new blood vessels from
pre-existing vessels. Angiogenesis may be promoted by growth factors and in diseases such as
cancer, where growth factors are over expressed, the body loses the ability to maintain a
balanced angiogenesis. This may embellish the existing supplies of blood; potentially
increasing the delivery of oxygen and nutrients supplies for cancer growth and survival.
Ramucirumab is an angiogenesis inhibitor; and is believed to block the promotion of the
growth factor to form new blood vessels, thus reducing the blood supply to the cancer cells.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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