Intralesional Versus Intramuscular Methotrexate for Non-melanoma Skin

Clinical Trial Description

Intralesional methotrexate (MTX) could to be promising conservative alternative for non-melanoma skin cancer (NMSC). Systemic MTX was attempted as adjuvant for locally-advanced NMSC. ;

Study Design

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04160065` - Immunotherapy With IFx-Hu2.0 Vaccine for Advanced Non-melanoma Skin Cancers	Phase 1
Recruiting	`NCT06409195` - A Trial to Study the Safety and Efficacy of SM-020 Gel 1.0% in Subjects With Seborrheic Keratoses and Non-Melanoma Skin Cancers	Phase 2
Completed	`NCT02423863` - In Situ, Autologous Therapeutic Vaccination Against Solid Cancers With Intratumoral Hiltonol®	Phase 2

See also

Status

Clinical Trial

Phase

Active, not recruiting

NCT04160065 - Immunotherapy With IFx-Hu2.0 Vaccine for Advanced Non-melanoma Skin Cancers

Phase 1

Recruiting

NCT06409195 - A Trial to Study the Safety and Efficacy of SM-020 Gel 1.0% in Subjects With Seborrheic Keratoses and Non-Melanoma Skin Cancers

Phase 2

Completed

NCT02423863 - In Situ, Autologous Therapeutic Vaccination Against Solid Cancers With Intratumoral Hiltonol®

Phase 2

Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.

Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.

Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

NCT number	NCT05315128
Study type	Interventional
Source	Zagazig University
Contact
Status	Completed
Phase	Phase 2
Start date	July 6, 2020
Completion date	December 6, 2021

Intralesional Versus Intramuscular Methotrexate for Non-melanoma Skin Cancers

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms