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NCT05550766 Clinical Trial

Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma

Non-melanoma Skin Cancer Clinical Trial

Official title:
Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma: An Immunohistochemical Study.

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05550766
Other study ID # Soh-Med-22-09-05
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date December 2022
Est. completion date December 2023

Study information
Verified date September 2022
Source Sohag University
Contact Fatma M.Hamdan
Phone 01000419587
Email fatma.mohammad@med.sohag.edu.eg
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell. This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell. Retinoid receptors are a superfamily of nuclear receptors. The preferred receptor that attaches to VDR is RXR, with its subunits α, β and γ. RXR α is more frequent in the skin than other tissues, while β occurs in internal organs and γ is frequently related to neural disorders. the investigator hopes to assess prognosis of SCC & BCC by using RXR-α biomarker & attempts to use it in the treatment.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 50
Est. completion date December 2023
Est. primary completion date September 2023
Accepts healthy volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: 1. Squamous cell carcinoma and basal cell carcinoma. 2. Incisional & excisional biopsies. 3. All the studied cases include sufficient materials for the immunohistochemical study 4. Complete clinical data Exclusion Criteria: 1. Patients with a history of preoperative chemotherapy and/or radiotherapy. 2. Insufficient or tiny tissue biopsies.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Sohag University

Outcome
Type Measure Description Time frame Safety issue
Primary Prognostic Value of RXR-a in Cutaneous Squamous and Basal Cell Carcinoma immuohistochemical expression of RXR-a in Squamous and Basal Cell Carcinoma One or two days after staining sections with the marker.
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