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Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma

Non-melanoma Skin Cancer Clinical Trial

Official title:
Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma: An Immunohistochemical Study.

Clinical Trial Summary

Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell. This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell. Retinoid receptors are a superfamily of nuclear receptors. The preferred receptor that attaches to VDR is RXR, with its subunits α, β and γ. RXR α is more frequent in the skin than other tissues, while β occurs in internal organs and γ is frequently related to neural disorders. the investigator hopes to assess prognosis of SCC & BCC by using RXR-α biomarker & attempts to use it in the treatment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05550766
Study type Observational
Source Sohag University
Contact Fatma M.Hamdan
Phone 01000419587
Email fatma.mohammad@med.sohag.edu.eg
Status Not yet recruiting
Phase
Start date December 2022
Completion date December 2023
View Details
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