Clinical Trials Logo

Clinical Trial Summary

This is a single institution, randomized, placebo-controlled, double-blind phase IIB trial of 1) topical diclofenac and topical DFMO, or 2) placebo in participants with a history of non melanoma skin cancer/ keratinocytic cancers.


Clinical Trial Description

There will be two groups to the study. Individuals, aged 18 years or older, who have extensive actinic damage, at least 8 AKs and a history of at least one non-melanoma skin cancer, but are in otherwise general good health, will be given topical diclofenac and topical DFMO. They will be compared to individuals, aged 18 years or older, who have extensive actinic damage, but are in otherwise general good health, will be given placebo. All participants must be at increased risk of non-melanoma skin cancer as evidenced by a history of prior squamous or basal cell skin cancer, ongoing or history of actinic keratoses, and the presence, at baseline, of at least eight actinic keratoses on the face, neck, scalp and arms. Subjects will be randomized to: 1. topical diclofenac once daily and topical DFMO once daily 2. placebo for the topical diclofenac once daily and placebo for the topical DFMO once daily ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04091022
Study type Interventional
Source University of Alabama at Birmingham
Contact
Status Active, not recruiting
Phase Phase 2
Start date January 18, 2021
Completion date December 1, 2024

See also
  Status Clinical Trial Phase
Not yet recruiting NCT04103658 - NIR and Skin Cancer Margins N/A
Completed NCT01053819 - Can We Miss Pigmented Lesions in Psoriasis Patients? Phase 4
Recruiting NCT03767348 - Study of RP1 Monotherapy and RP1 in Combination With Nivolumab Phase 2
Recruiting NCT05429866 - Immunological Variables Associated to ICI Toxicity in Cancer Patients Phase 2
Active, not recruiting NCT02636569 - Topical Chemoprevention of Skin Cancer Biomarkers Phase 2
Completed NCT02760160 - Dietary Prevention of Photodamage in Skin With Grapes N/A
Completed NCT02780934 - Comparing Pressure Versus Simple Adhesive Dressing After Mohs Reconstruction N/A
Completed NCT02872909 - Randomized Comparison of Low and Conventional Irradiance PDT for Skin Cancer N/A
Withdrawn NCT03327064 - A Biomarker Evaluation Trial of UAB30 in Renal Transplant Recipients at High Risk for Non-melanoma Skin Cancer Phase 1/Phase 2
Completed NCT00342407 - The Incidence of Breast and Other Cancers Among Female Flight Attendants
Terminated NCT04410874 - Imvamune Vaccine for the Treatment of Non-melanoma Skin Cancer Phase 1/Phase 2
Completed NCT03693937 - A Retrospective Evaluation of Superficial Radiation Therapy (SRT) and Non-Melanoma Skin Cancer (NMSC)
Completed NCT04334824 - Hydrochlorothiazide and Risk of Skin Cancer
Recruiting NCT05878288 - Deep sequencIng in Cutaneous Squamous CEll caRciNomas Phase 2
Completed NCT01359735 - Healing Effects of HP802-247 Versus Antibiotic Ointment in Mohs Micrographic Surgery Patients Phase 2
Terminated NCT04348916 - Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors or With Liver Metastases of Solid Tumors Phase 1
Enrolling by invitation NCT05257486 - Post-market Multi-Center RETRO-Prospective Study to Assess Long-term Clinical Outcomes NMSC Patients Treated With eBx
Recruiting NCT06428721 - The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population N/A
Withdrawn NCT03757663 - UV Dosimetry Feedback in NMSC Patients N/A
Completed NCT04116983 - DERM NMSC Validation Study