Hypofractionated Radiotherapy for Nonmelanoma Skin Cancer

Status Terminated

Clinical Trial Summary

Radiotherapy is a treatment considered standard for non melanoma skin cancer. This institution uses schemes of 4 to 6 weeks of treatment. The objective of the study is to perform radiation therapy in 1 to 2 weeks, depending on the size of the lesion.

Clinical Trial Description

Delineation of radiation field

- Gross tumor volume (GTV): disease clinically visible / palpable

- clinical target volume (CTV): equal to GTV

- planned treatment volume (PTV):

- tumors ≤ 2 cm in diameter, with 5-10 mm CTV margin

- tumors> 2-5 cm in diameter, with 15-20 mm CTV margin

- Marking the GTV and PTV pen back projection

- photograph of the treatment area

- protections of the normal structures with blocks of lead, if necessary

Technical

- Distance focus-skin Tube: 35 cm Locator: 30 and 40 cm

- Sizes Tube: 2, 3 and 4 cm in diameter Finder: 6x8 cm, 8x10 cm

- Energy:

80 kV 140 kv

- Filter 80 kV, 2 mm Al 140 kv, 0.5 mm Copper

- Current Draw: 20 mA

Dose

- tumors ≤ 2 cm in diameter: 5 fractions of 600 cGy, once a day, five times a week - TDF: 89

- tumors > 2-5 cm in diameter: 10 fractions of 400 cGy, once a day, five times a week - TDF: 96

Clinical revisions every 5 weekly sessions, or a weekly and at the end of treatment. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02080962
Study type	Interventional
Source	Barretos Cancer Hospital
Contact
Status	Terminated
Phase	Phase 2
Start date	January 2011
Completion date	February 2014

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT04103658` - NIR and Skin Cancer Margins	N/A
Completed	`NCT01053819` - Can We Miss Pigmented Lesions in Psoriasis Patients?	Phase 4
Recruiting	`NCT03767348` - Study of RP1 Monotherapy and RP1 in Combination With Nivolumab	Phase 2
Recruiting	`NCT05429866` - Immunological Variables Associated to ICI Toxicity in Cancer Patients	Phase 2
Active, not recruiting	`NCT02636569` - Topical Chemoprevention of Skin Cancer Biomarkers	Phase 2
Completed	`NCT02780934` - Comparing Pressure Versus Simple Adhesive Dressing After Mohs Reconstruction	N/A
Completed	`NCT02760160` - Dietary Prevention of Photodamage in Skin With Grapes	N/A
Completed	`NCT02872909` - Randomized Comparison of Low and Conventional Irradiance PDT for Skin Cancer	N/A
Withdrawn	`NCT03327064` - A Biomarker Evaluation Trial of UAB30 in Renal Transplant Recipients at High Risk for Non-melanoma Skin Cancer	Phase 1/Phase 2
Completed	`NCT00342407` - The Incidence of Breast and Other Cancers Among Female Flight Attendants
Terminated	`NCT04410874` - Imvamune Vaccine for the Treatment of Non-melanoma Skin Cancer	Phase 1/Phase 2
Completed	`NCT03693937` - A Retrospective Evaluation of Superficial Radiation Therapy (SRT) and Non-Melanoma Skin Cancer (NMSC)
Completed	`NCT04334824` - Hydrochlorothiazide and Risk of Skin Cancer
Recruiting	`NCT05878288` - Deep sequencIng in Cutaneous Squamous CEll caRciNomas	Phase 2
Completed	`NCT01359735` - Healing Effects of HP802-247 Versus Antibiotic Ointment in Mohs Micrographic Surgery Patients	Phase 2
Terminated	`NCT04348916` - Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors or With Liver Metastases of Solid Tumors	Phase 1
Enrolling by invitation	`NCT05257486` - Post-market Multi-Center RETRO-Prospective Study to Assess Long-term Clinical Outcomes NMSC Patients Treated With eBx
Recruiting	`NCT06428721` - The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population	N/A
Withdrawn	`NCT03757663` - UV Dosimetry Feedback in NMSC Patients	N/A
Completed	`NCT04116983` - DERM NMSC Validation Study