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Non-malignant Diseases clinical trials

View clinical trials related to Non-malignant Diseases.

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NCT ID: NCT02162511 Completed - Clinical trials for Non-malignant Diseases

CD34+ Cell Enriched and T Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Mismatched Related Donors or Borderline Organ Function

Start date: May 2014
Phase: N/A
Study type: Interventional

The purpose of this protocol is to provide access to the CliniMACS® System to hematopoietic cell transplant (HSCT) patients who do not have a matched related donor. The CliniMACS system is currently approved for use in patients who have AML, and a genetically matched sibling donor. Through this protocol, the investigators will be able to offer potentially life-saving transplants to patients who have genetically mis-matched donor, who have no other options for treatment.

NCT ID: NCT01050855 Active, not recruiting - Hemoglobinopathies Clinical Trials

Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders

RIC
Start date: January 2008
Phase: Phase 2
Study type: Interventional

This is a Phase II pilot study to evaluate engraftment and toxicity of patients with non-malignant diseases using a reduced intensity conditioning regimen in the setting of allogeneic transplant for non malignant diseases. Bone Marrow or cord blood will be acceptable as a stem cell source. Recently, reduced intensity conditioning (RIC) regimens have been used for both adult patients with leukemias and pediatric patients with non-malignant diseases. These regimens are better tolerated, resulting in less transplant related morbidity and mortality. Stable mixed chimerism, while insufficient for eradication of leukemias, may be sufficient to cure patients with non-malignant diseases.