A Phase I Dose Escalation Study of RAD001 Administered in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Non-Hodgkin's Lymphoma Clinical Trial

Official title:

A Phase I Dose Escalation Study of RAD001 Administered in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00622258
• Other study ID #: CRAD001C1104
• Status: Completed
• Phase: Phase 1
• Start date: March 2008
• Est. completion date: January 2014

Study information

• Verified date: September 2014
• Source: Novartis
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study assesses the tolerability, safety, efficacy and pharmacokinetics of everolimus in Japanese patients. Everolimus is administered orally everyday to adult patients with relapsed or refractory non-Hodgkin's lymphoma who have progressed despite standard therapy or for whom standard systemic therapy dose not exist.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: January 2014
• Est. primary completion date: January 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion criteria:

• Patients must have histopathologically confirmed diagnosis of non-Hodgkin's lymphoma

• Patients must have disease that is either relapsed or refractory after at least one prior treatment regimen and must not be eligible for any standard treatments

• Patients must not have received autologous stem cell transplant at least within 12 weeks prior to study treatment. If patients received autologous stem cell transplant more than 12 weeks ago, they must be fully recovered from the side effects of such treatment

• Patients who have not received autologous stem cell transplant must be either ineligible for the treatment or, if eligible, patients must have chosen not to receive stem cell transplant

• Patients must have at least one measurable lesion

• Age above 20 years old

• Performance Status 0, 1, or 2 on Eastern Cooperative Oncology Group (ECOG) scale

• Patients with a life expectancy of at least 12 weeks

• Patients must be willing to provide portion of bone marrow aspirate and biopsy during study

Exclusion criteria:

• Patients with history of another primary malignancy that is currently clinically significant or currently requires active intervention

• Patients with prior allogeneic stem cell transplant

• Patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study

• Patients who have received radiation therapy for = 28 days prior to first study treatment or who have not recovered from side effects of such therapy.

• Patients who have received any other investigational agents =28 days prior to the first study treatment

• Patients who have received anti-neoplastic therapy within 28 days (60 days for monoclonal antibody or radioimmunotherapy) prior to the first study treatment or who have not recovered from side effects of such therapy

• Patients who have received treatment with oral or intravenous steroids or any immunosuppressive agents = 28 days prior to the first study treatment

• Patients who have received prior therapy with RAD001 or other mTOR inhibitors

• Patient with prior therapy of > 450 U blomycin

• Patients with an active, bleeding diathesis.

• Treatment with any hematopoietic colony-stimulating growth factors (e.g., G-CSF) = 14 days prior to the first study treatment

• Patients who have an impairment of gastrointestinal function or who have gastrointestinal disease that may significantly alter the absorption of study treatment (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome)

• Patients with active respiratory (excluding interstitial lung disease), skin, mucosal, renal, neurological, or ocular disorder of grade > 1

• Patients with a history of interstitial lung disease of grade = 1

• Patients with a known history of human immunodeficiency virus seropositivity, hepatitis B or C seropositivity

Other protocol-defined inclusion/exclusion criteria may apply

Related Conditions & MeSH terms

• Lymphoma
• Lymphoma, Non-Hodgkin
• Non-Hodgkin's Lymphoma

Intervention

Drug:
• Everolmus

Locations

Country	Name	City	State
Japan	Novartis Investigative Site	Chuo-ku	Tokyo
Japan	Novartis Investigative Site	Fukuoka
Japan	Novartis Investigative Site	Isehara-city	Kanagawa
Japan	Novartis Investigative Site	Kashiwa	Chiba
Japan	Novartis Investigative Site	Kyoto
Japan	Novartis Investigative Site	Nagoya	Aichi
Japan	Novartis Investigative Site	Nagoya-city	Aichi
Japan	Novartis Investigative Site	Sendai-city	Miyagi

Sponsors (1)

Lead Sponsor	Collaborator
Novartis Pharmaceuticals

Country where clinical trial is conducted

Japan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To assess the safety and tolerability of RAD001 in Japanese patients with relapsed or refractory non-Hodgkin's lymphoma		whole study period
Primary	To assess the pharmacokinetics in Japanese patients		1st sycle
Secondary	To seek preliminary evidence of efficacy in this population		Every 2 cycles

External Links

•   Results for CRAD001C1104 can be found on the Novartis Clinical Trial Results Website
•   Visit NovartisClinicalTrials.com: Pre-qualify for a trial, and view a list of trials and participating study centers.