Duvelisib Following Chimeric Antigen Receptor T-Cell Therapy

Status Recruiting

Clinical Trial Summary

While chimeric antigen receptor T-cell (CAR T-cell) therapy produces impressive response rates in heavily pre-treated patients, early loss of response remains a barrier. One potential mechanism of relapse is limited CAR T-cell persistence. Pre-clinical research shows that PI3K inhibition represents an intriguing mechanism for increasing CAR T-cell persistence that is easily reversible and CAR T-cell agnostic. The investigators hypothesize that PI3K inhibition with duvelisib would be safe, may provide effective prophylaxis against cytokine release syndrome (CRS), and may enhance the persistence and efficacy of CAR T-cells in the treatment of hematologic malignancies.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Acute Lymphocytic Leukemia
Non-hodgkin Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Clinical Trial Details

NCT number	NCT05044039
Study type	Interventional
Source	Washington University School of Medicine
Contact	Armin Ghobadi, M.D.
Phone	314-454-8304
Email	arminghobadi@wustl.edu
Status	Recruiting
Phase	Phase 1
Start date	February 28, 2022
Completion date	May 31, 2030

View Details

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