Non Hodgkin Lymphoma Clinical Trial
Official title:
Clinical Study to Evaluate the Safety and Efficacy of IM19 CAR-T Cell Therapy in Patients With Relapsed or Refractory CD19-positive Non-Hodgkin's Lymphoma
n this study, approximately 30 patients with relapsed or refractory non-Hodgkin's lymphoma (NHL) were recruited for a single reinfusion of IM19-CD28 and IM19-41BB CAR-T cells. Assess the safety, tolerability of treatment, and initially observe the efficacy.
1. Dose-escalation:Patients entered the IM19-41BB or IM19-CD28 group and performed dose
escalation studies in three dose groups.
2. According to the results of the previous dose escalation study, select one dose to
continue the enrollment of 6 patients for extended studies.
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