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AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Non Hodgkin Lymphoma

Non-Hodgkin Lymphoma Clinical Trial

Official title:
Phase I Clinical Trial of AntiCD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non Hodgkin Lymphoma

Clinical Trial Summary

The purpose of this study is to determine if it is possible to treat your cancer with a new type of T cell-based immunotherapy (therapy that uses your immune system to treat the cancer). T cells are a type of white blood cell that helps the body fight infections. This treatment uses T cells already present within your body that have been modified outside of the body and returned to target your cancer. This type of treatment is sometimes referred to as adoptive cell transfer (ACT). In this study the specific type of cells that will be used is called chimeric antigen receptor T cells (CAR T cells). Another purpose of this study is to learn about the side effects and toxicities related to this treatment.

Clinical Trial Description

Primary Objective: To determine the safety of the treatment of relapsed or refractory B cell lymphomas with chimeric antigen receptor T cells targeting cluster of differentiation antigen 19 (CD19) and to find the recommended phase II dose for this cellular therapy Secondary Objectives - To describe the safety profile of the infusion of CAR-T cells targeting CD19. - To describe the toxicities related to infusion of CAR-T cells targeting CD19. - To describe the overall response rate and complete response rate of relapsed B cell malignancies treated with CAR-T cells targeting CD19. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03434769
Study type Interventional
Source Case Comprehensive Cancer Center
Contact
Status Active, not recruiting
Phase Phase 1
Start date July 9, 2018
Completion date February 2036
View Details
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