Ulcer Foot Clinical Trial
Official title:
Platelet Rich Plasma (PRP) Bio Stimulant Gel Dressing in Treating Chronic Non Healing Leg and Foot Ulcers: Cost and Effectiveness
Background
Chronic non-healing ulcer is a common problem met in clinical practice and represents a
burden to the patients. Chronic ulcer lacks growth factors (GFs) to promote the healing
process and is frequently followed by superadded infections. Ordinary technique such as wound
debridement and regular dressings cannot provide adequate results as these techniques cannot
provide the necessary GFs. Platelet-rich plasma (PRP) helps wound healing by releasing
various types of GFs.
The aim: to evaluate and compare the efficacy of PRP dressing versus traditional dressings in
the treatment of chronic non-healing leg and foot ulcers of different etiology as regard cost
of overall treatment and effectiveness (reduction of the size of the ulcer and safety of the
technique).
Methods
This prospective study was performed on inpatients and outpatients in general surgery
department, Zagazig university hospital from June 2017 to January 2019. Patients were divided
randomly into two groups: group A received PRP dressing (N=22, 50%) and group B received
conventional ordinary dressing (N=22, 50%).The mean follow-up period was 3 months after the
last dressing. Patients treated with PRP at once-weekly interval for a maximum of 12
dressings while patients with ordinary dressings may need one dressing every other day for a
maximum of 12 weeks. The reduction in the size of the ulcers (area and volume) in both groups
was assessed using centimeter scale and Digital photographs before and after each session and
during follow up period.
Keywords: Platelet-rich plasma, ulcers, non-healing, ordinary dressing.
Chronic non-healing ulcer is a common problem met in clinical practice and represents a
burden to the patients. Chronic ulcer lacks growth factors (GFs) to promote the healing
process and is frequently followed by superadded infections. Ordinary technique such as wound
debridement and regular dressings cannot provide adequate results as these techniques cannot
provide the necessary GFs. Platelet-rich plasma (PRP) helps wound healing by releasing
various types of GFs.
The aim: to evaluate and compare the efficacy of PRP dressing versus traditional dressings in
the treatment of chronic non-healing leg and foot ulcers of different etiology as regard cost
of overall treatment and effectiveness (reduction of the size of the ulcer and safety of the
technique).
Methods
This prospective study was performed on inpatients and outpatients in general surgery
department, Zagazig university hospital from June 2017 to January 2019. Patients were divided
randomly into two groups: group A received PRP dressing (N=22, 50%) and group B received
conventional ordinary dressing (N=22, 50%).The mean follow-up period was 3 months after the
last dressing. Patients treated with PRP at once-weekly interval for a maximum of 12
dressings while patients with ordinary dressings may need one dressing every other day for a
maximum of 12 weeks. The reduction in the size of the ulcers (area and volume) in both groups
was assessed using centimeter scale and Digital photographs before and after each session and
during follow up period.
Keywords: Platelet-rich plasma, ulcers, non-healing, ordinary dressing.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT03675269 -
Adjunctive Hyperbaric Oxygen Therapy (HBOT) for Lower Extermity Diabetic Ulcer:
|
N/A | |
| Terminated |
NCT05234632 -
Study to Evaluate the PICO 14 Negative Pressure Wound Therapy System in the Management of Acute and Chronic Wounds
|
N/A | |
| Not yet recruiting |
NCT04537676 -
Patient Empowerment Study
|
||
| Completed |
NCT05101473 -
Exercise Therapy for People With a Diabetic Foot Ulcer - a Feasibility Study
|
N/A | |
| Recruiting |
NCT04210089 -
Total Contact Soft Cast in Diabetic Foot Ulcers
|
N/A | |
| Completed |
NCT03985306 -
Treatment of Diabetic Foot Ulcers With Inforatio Technique to Promote Wound Healing
|
N/A | |
| Completed |
NCT05564728 -
Diabetes Footcare Companion App for Patients and Carers
|
||
| Not yet recruiting |
NCT06449638 -
Modified Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of Hard-to-Heal DFUs
|
N/A | |
| Completed |
NCT03883230 -
Wound Infection Detection Evaluation, WIDE
|
||
| Completed |
NCT05883098 -
SDRM® vs. Collagen for Diabetic Foot Ulcers
|
N/A | |
| Completed |
NCT02986256 -
Evaluation of the Management of Diabetic Foot Ulcers by Telemedicine on the Number of Hospital Days in Diabetic Patients
|
N/A | |
| Terminated |
NCT03479242 -
Diabetic Foot Ulcer Recurrence: Pilot Study
|
||
| Recruiting |
NCT06124586 -
Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS)
|
N/A | |
| Not yet recruiting |
NCT05251480 -
Examining the Effectiveness of DermGEN™ in the Treatment of Diabetic Foot Ulcers in First Nations People
|
N/A | |
| Completed |
NCT03398538 -
Resorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers
|
N/A | |
| Recruiting |
NCT03270904 -
Moleculight i:X™ in Wound Healing
|
N/A | |
| Terminated |
NCT04123093 -
Safety and Efficacy of the Noxsano Wound Care Bandage
|
N/A | |
| Completed |
NCT04040426 -
Bioactive Split Thickness Skin Allograft Versus Standard of Care in the Treatment of Diabetic Foot Ulcers
|
N/A | |
| Recruiting |
NCT06403605 -
Bioresorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers
|
N/A | |
| Completed |
NCT03881254 -
SkinTE™ in the Treatment of Diabetic Foot Wounds
|
N/A |