Non-epileptic Seizures Clinical Trial
Official title:
Neuropsychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure
This study will explore how the mind and the brain work to cause movement symptoms or
seizures in people who do not have a recognized neurological or medical disorder. The study
includes a check for psychiatric disorders, symptoms and their severity; psychiatric and
personality questionnaires; and neuropsychological testing.
Normal, healthy volunteers, people who have movement symptoms not due to a brain or medical
disorder and people who have seizures not due to epilepsy may be eligible for this study. All
candidates must be 18 years of age or older.
All participants have a medical history, physical examination and psychological evaluation,
including completion of questionnaires. People with movement symptoms or seizures have a
symptoms evaluation.
Some participants also undergo neuropsychological testing, including questionnaires,
pen-and-paper or computerized tests, and motor tasks.
Objectives
The objectives of this study are (1) to investigate the relationship between childhood abuse
and dissociative experiences in both psychogenic movement disorders (PMD) and non-epileptic
seizures (NES) and (2) to investigate the relationship between childhood abuse and both PMD
and NES. The secondary objective of the study is to investigate if measures of response
inhibition differ between PMD subjects compared to normal controls. This study is part of a
larger study investigating the psychological and biological correlates of conversion
disorder.
Study population
We intend to study adult patients with diagnoses of PMD seen by the Human Motor Control
Section clinic or patients with diagnoses of NES seen by the Epilepsy clinic and normal
controls.
Design
A psychiatric assessment, measurement scales and neuropsychological testing will be
administered to the PMD and NES patients and normal controls.
Outcome measures
The first primary outcome measure will be the comparison of the different subtypes of
childhood abuse (as measured by the Childhood Trauma Interview) and the severity of
dissociation (as measured by the Dissociative Experiences Scale). The second primary outcome
measure will be the comparison of frequencies of different subtypes of childhood abuse (as
measured by the Childhood Trauma Interview) between PMD, NES and normal control groups. The
secondary outcome measure will be the comparison of stop-signal reaction time as measured
with the stop-signal task.
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