The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

Non-Cardiac Chest Pain Clinical Trial

Official title:

Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pian in Chinese? Part I: The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00164814
• Other study ID #: NPA study
• Status: Terminated
• Phase: N/A
• First received: September 9, 2005
• Last updated: March 25, 2008

Study information

• Verified date: March 2008
• Source: Chinese University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Health authority: Hong Kong: Department of Health
• Study type: Observational

Clinical Trial Summary

Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease. Despite its benign nature, this condition causes anxiety, impairs quality of life and consumes a substantial amount of healthcare resources. While acid reflux and motility disorder in the esophagus are often attributed as the cause of NCCP, visceral hyperalgesia of esophagus is now recognized to play a central role in the pathogenesis of this condition. This research project aims to evaluate the role of visceral hyperalgesia in Chinese patients with NCCP. NCCP patients will be evaluated for the prevalence of gastroesophageal reflux disease and esophageal motility disorder by endoscopy, manometry and pH study. The visceral sensory and pain thresholds of these patients will be compared with asymptomatic controls.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 100
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy

• Age between 18-70

Exclusion Criteria:

• Gastroesophageal reflux disease

• Psychiatric illness

• Cerebrovascular accident

• Active peptic ulceration

• Heart failure or cardiac bradyarrhythmia

• Epilepsy

• Pregnancy or lactating female

• Previous hypersensitivity to muscle relaxant

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Chest Pain
• Esophageal Motility Disorders
• Esophageal Spasm, Diffuse
• Gastroesophageal Reflux
• Hyperalgesia
• Non-Cardiac Chest Pain

Locations

Country	Name	City	State
China	Endoscopy Centre, Prince of Wales Hospital	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

China,