Effect of GABAB Agonist on Visceral Hyperalgesia in NCCP patientsChinese?

Non-Cardiac Chest Pain Clinical Trial

Official title:
Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pain in Chinese? Part 2: Effect of GABAB Agonist on Visceral Hyperalgesia in NCCP Patients

Status Terminated

Clinical Trial Summary

The effect of baclofen (GABAB agonist), diltiazem (muscle relaxant) and placebo will be compared in a double-blinded randomized study for the treatment of NCCP. Cerebral cortical, brainstem and spinal evoked potentials before and after treatment will be evaluated. Results of this study will shed lights on pathogenesis and treatment of NCCP in Chinese.We hypothesize that Baclofen alleviates visceral hyperalgesia in NCCP patients by suppressing afferent sensory pathway.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00164801
Study type	Interventional
Source	Chinese University of Hong Kong
Contact
Status	Terminated
Phase	N/A
Start date	November 2004
Completion date	January 2007

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See also
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Completed	`NCT00462241` - Treatment Study Comparing Manual Treatment or Advice in Acute, Musculoskeletal Chest Pain	N/A
Terminated	`NCT00164814` - The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients	N/A