Nocturia Clinical Trial
Official title:
The Effect of Gender on Antidiuresis - Evaluated by Graded Low Dose Desmopressin Infusion
There is substantial evidence that women throughout life have significantly lower plasma
levels of the antidiuretic hormone vasopressin (pAVP) compared to men. The importance of
this is not yet fully elucidated, but in relation to the observations of lower pAVP levels,
no significant difference in renal response parameters was found. This could be interpreted
an increased renal sensitivity in females compared to males. The theory of increased renal
sensitivity in females is supported by a few pharmacodynamic studies currently available on
this topic. However none of the studies was designed with the purpose of investigate the
gender difference.
The aim of this study is to investigate possible gender differences in the renal sensitivity
to dDAVP and the effect of age on these differences. This will be done by low dose graded
infusion of the synthetic AVP analog dDAVP.
Participants are 80 healthy volunteers equally distributed between four age groups, 8-10
years of age, 16-18 years of age, 25-40 years og age and 65+ years of age.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03623880 -
Enhancing Behavioral Treatment for Women With Pelvic Floor Disorders
|
N/A | |
| Completed |
NCT02905682 -
Trial of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Female Subjects
|
Phase 3 | |
| Completed |
NCT02835846 -
Investigation of the Effect of the Female Urinary Microbiome on Incontinence
|
Phase 4 | |
| Completed |
NCT02904759 -
Trial of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Male Subjects
|
Phase 3 | |
| Completed |
NCT01520948 -
Behavioral Therapy to Treat Urinary Symptoms in Parkinson Disease
|
Phase 3 | |
| Completed |
NCT01684800 -
Comparative Trial to Investigate the Efficacy and Safety of Desmopressin for the Treatment of Nocturia in Adult Women
|
Phase 2 | |
| Completed |
NCT01694498 -
Comparative Trial to Investigate the Efficacy and Safety of Desmopressin for the Treatment of Nocturia in Adult Men
|
Phase 2 | |
| Completed |
NCT01222598 -
A Study of Minirin Melt in Patients With Nocturia
|
N/A | |
| Recruiting |
NCT04305743 -
Post-procedural Pain Associated With 5 Versus 20 Intravesical Injections of Onabotulinumtoxin A
|
Phase 4 | |
| Completed |
NCT01486706 -
Efficacy and Safety of Gabapentin in Treating Overactive Bladder
|
Phase 2/Phase 3 | |
| Completed |
NCT04528784 -
Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis
|
N/A | |
| Recruiting |
NCT05874375 -
UCon Treatment of Overactive Bladder (OAB) in Males
|
N/A | |
| Completed |
NCT01223937 -
Investigation of the Superiority Effect of Desmopressin to Placebo in Terms of Night Voids Reduction in Nocturia Adult Female Patients
|
Phase 3 | |
| Withdrawn |
NCT01018225 -
Exploratory Study Evaluating the Effects of Darifenacin on Nocturia, Sleep and Daytime Wakefulness
|
Phase 4 | |
| Completed |
NCT05222477 -
Abdominal Muscle Exercises on Nocturia and Sleep Quality in Women With Type 2 Diabetes
|
N/A | |
| Withdrawn |
NCT02961114 -
Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy
|
Phase 1/Phase 2 | |
| Completed |
NCT02440841 -
Study in Healthy Male Subjects to Evaluate the Effect of Itraconazole and Rifampicin on the PK of Fedovapagon
|
Phase 1 | |
| Completed |
NCT01357356 -
Multicenter Study to Investigate SER120 Nasal Spray Formulations in Patients With Nocturia
|
Phase 2/Phase 3 | |
| Completed |
NCT02151253 -
Cross-over Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia
|
Phase 2/Phase 3 | |
| Completed |
NCT00700583 -
Alpha-blocker Plus Diuretic Combination Therapy as Second-line Treatment for Nocturia in Men
|
N/A |