Nocturia Clinical Trial
In patients with nocturia, combinational treatment of DDAVP and SyBeMeP might show better
outcomes.
Systemic video instruction might prove to be beneficial by helping patients have better
understanding on treatment and replacing healthcare personnel.
One of main reason of nocturia is known as nocturnal polyuria. For the treatment of nocturia
caused by overactive bladder, the combined therapy of anticholinergics plus behavioural
modification has been established as the first line therapy. However, nocturia mainly comes
from polyuria has been treated with desmopressin pharmacotherapy and the effect of behaviour
modification education has not yet evaluated. Therefore, in this study, short term
synergistic effect of combinational treatment of desmopressin and SyBeMeP (Systemized
Behavioral Modification education Program) comparing desmopressin monotherpy will be
evaluated in patients with nocturia.
Control group: Desmopressin (Minirin Tablet 0.1-0.4mg/day) + simple instruction Study group:
Desmopressin (Minirin Tablet 0.1-0.4mg/day) + SyBeMeP. Patients will be randomized and
assigned to each group at the ratio of 1:1. At screening visit, flowmetry and residual urine
measurement, Complete Blood Count (CBC), atypical diabetes mellitus (ADM), electrolytes,
urinalysis micro, urine concentration, and demographic examination will be done. Voiding
diary will be distributed. At 2nd visit, patients will be randomized and each treatment will
be initiated. IPSS, ICIQ-nocturia, and PPTB will be completed. Voiding diary will be
distributed. At 3rd visit (2 weeks after from 2nd visit): IPSS, ICIQ-nocturia, and PPTB will
be completed. Assess the treatment outcome including voiding diary analysis.
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Observational Model: Case Control, Time Perspective: Prospective
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