Intake Duration Effects of Blackcurrant on Cardiovascular and Metabolic Responses

no Conditions Clinical Trial

Official title:

Effects of Intake Duration of New Zealand Blackcurrant Extract on Physiological, Cardiovascular and Metabolic Responses at Rest and During Moderate-intensity Exercise in Healthy Males

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05067062
• Other study ID #: MW1718NZBCduration
• Status: Completed
• Phase: N/A
• Start date: September 1, 2017
• Est. completion date: September 1, 2018

Study information

• Verified date: October 2021
• Source: University of Chichester
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.

Description:

The investigators will examine effects of acute intake, intermittent intake and chronic intake of New Zealand blackcurrant extract using indirect calorimetry and hemodynamic measurements.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: September 1, 2018
• Est. primary completion date: September 1, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Healthy

• Non-smokers

• Not taking any supplements

• No known allergy to berries or berry products

Exclusion Criteria

• Sedentary

• Known high blood pressure

• Smoking

• On medication

Related Conditions & MeSH terms

• no Conditions

Intervention

Dietary Supplement:
• New Zealand blackcurrant extract
Capsules taken daily or intermittent

Locations

Country	Name	City	State
United Kingdom	Mark Willems	Chichester	West Sussex

Sponsors (1)

Lead Sponsor	Collaborator
University of Chichester

Country where clinical trial is conducted

United Kingdom, 

References & Publications (2)

Sahin PhD MA, Bilgiç PhD P, Montanari MSc S, Willems PhD MET. Daily and Not Every-Other-Day Intake of Anthocyanin-Rich New Zealand Blackcurrant Extract Alters Substrate Oxidation during Moderate-Intensity Walking in Adult Males. J Diet Suppl. 2020 Oct 29: — View Citation

Sahin PhD MA, Bilgiç PhD P, Montanari MSc S, Willems PhD MET. Intake Duration of Anthocyanin-Rich New Zealand Blackcurrant Extract Affects Metabolic Responses during Moderate Intensity Walking Exercise in Adult Males. J Diet Suppl. 2021;18(4):406-417. doi: 10.1080/19390211.2020.1783421. Epub 2020 Jun 24. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in heart rate from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Heart rate will be measured in beats/min.	baseline, acute, one week and two weeks
Primary	Changes in stroke volume from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Stroke volume will be measured in mL.	baseline, acute, one week and two weeks
Primary	Changes in cardiac output from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Cardiac output will be measured in L/min.	baseline, acute, one week and two weeks
Primary	Changes in blood pressure from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Systolic, diastolic and mean arterial blood pressure will be measured in mmHg.	baseline, acute, one week and two weeks
Primary	Changes in total peripheral resistance from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise.; Total peripheral resistance will be measured in (mmHg·min)/L	baseline, acute, one week and two weeks
Secondary	Changes in oxygen consumption from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Oxygen consumption will be measured in L/min	baseline, acute, one week and two weeks
Secondary	Changes in carbon dioxide production from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Carbon dioxide production will be measured in L/min.	baseline, acute, one week and two weeks
Secondary	Changes in respiratory exchange ratio from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Respiratory exchange ratio is unitless and calculated from the ratio of carbon dioxide production and oxygen consumption.	baseline, acute, one week and two weeks
Secondary	Changes in carbohydrate oxidation from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Carbohydrate oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.	baseline, acute, one week and two weeks
Secondary	Changes in fat oxidation from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking.; Fat oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.	baseline, acute, one week and two weeks