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Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide — PROTORISC  

Suicidal Ideation Clinical Trial

Official title:
Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide - PROTORISC Pilote

Clinical Trial Summary

Suicide prevention is a major public health concern, with nearly 9,000 suicides and over 200,000 suicide attempts reported each year in France. Suicide attempts and suicidal ideation are among the most frequent reasons for emergency room visits and psychiatric hospitalizations. Although there is no approved pharmacological treatment for suicidal crises, some psychiatric treatments appear promising. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has shown promising results in reducing suicidal ideation. However, its use is limited due to its side effects. Nitrous oxide, another NMDA receptor inhibitor commonly used in anesthesia and pain management, has demonstrated rapid antidepressant effects and few side effects. Given its rapid and lasting effects, nitrous oxide could swiftly alleviate suicidal ideation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06430489
Study type Interventional
Source University Hospital, Tours
Contact ANAIS VANDEVELDE, MD, PHD
Phone +33247474747
Email anais.vandevelde@chu-tours.fr
Status Not yet recruiting
Phase Phase 2
Start date June 2024
Completion date January 2026
View Details
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