Nicotine Clinical Trial
Official title:
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes
The goal of this application is to test whether menthol and fruit flavors impact e-cigarette use through dissociable mechanisms and exert their effects differentially across nicotine doses.
This study examines the impact of menthol and fruit flavors on self-administration of e-cigarette solutions containing varying amounts of nicotine. This is a randomized, double-blind study with a within-subject cross-over design, using e-liquids with 5 different flavors and 4 different levels of nicotine for a total of 20 different e-liquid formulations. Each subject will participate in 4 test sessions. The order of flavor and nicotine delivery will be randomized. At each test session, they will undergo directed self-administration, in a randomized order, then an ad libitum self-administration session where they can choose among all of the e-cigarettes used during the directed session. The primary aims assess the impacts of nicotine and flavor (and their interactions) on participants' subjective ratings of the e-liquids during the 'directed' self-administration component, and self-administered puffs during the ad libitum self-administration component. In addition, the study will explore the impact of sex/gender and sensitivity to nicotine aversiveness or bitterness (as operationalized by genetic variations in the alpha-5 subunit of nicotinic acetylcholine receptor that influences the aversive effects of nicotine, or a taste receptor number 38 ( TAS2R38) important for bitterness perception) on study outcomes. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT03576768 -
QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt
|
N/A | |
Completed |
NCT04124432 -
Behavioral Pharmacology of Cannabis and Nicotine
|
Phase 1 | |
Completed |
NCT01223404 -
Nicotinic Modulation of the Default Network
|
N/A | |
Recruiting |
NCT05864586 -
Developing E-liquid Product Standards (Sweet Spot Study)
|
N/A | |
Completed |
NCT01227343 -
Nicotine and Brain Imaging Research Study
|
||
Completed |
NCT05317195 -
Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouch 1.0 Compared to Velo® Ice Cool and Zyn® Cool Mint Mini Dry in Healthy Smokers
|
N/A | |
Withdrawn |
NCT03010995 -
The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
|
Phase 1 | |
Active, not recruiting |
NCT04189146 -
Inner Engineering Yoga Program on Short and Long Term Health Effects (ISHA-Impact): A Longitudinal Study
|
N/A | |
Completed |
NCT05487456 -
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
|
N/A | |
Completed |
NCT03102931 -
Switching to Low Oxidant Content Cigarettes in Adult Smokers
|
N/A | |
Completed |
NCT03134339 -
The Effect of Nicotine Delivery Rate on Reinforcement
|
Early Phase 1 | |
Recruiting |
NCT06346353 -
Substance Consumption, Personality, and Cognitive Functioning of Chess Players
|
||
Completed |
NCT05383508 -
Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes
|
N/A |