Nicotine Clinical Trial
Official title:
Sex, GABA and Nicotine: A 1H-MRS Study
The aim of this study is to assess the impact of smoking on cortical GABA levels in males and females. Using magnetic resonance spectroscopy (MRS), we will examine the impact of sex and menstrual cycle phase on brain neurochemistry in healthy smokers and non-smokers. We hypothesize that female, but not male, smokers will have reduced cortical GABA levels compared to their non-smoking, sex-matched counterparts.
The purpose of this study is to measure and compare gamma-aminobutyric acid (GABA) levels in the occipital cortex of a group of healthy smoking and non-smoking women and men ages 18-50. We will recruit women with regular menstrual cycles so that we can assess premenstrual impact of smoking cessation in that population and compare GABA level concentrations across all groups. Although there are several note-worthy differences between male and females in regard to smoking behavior, ultimately none are as worrisome as the disparity in ability to quit smoking. While multiple explanations for why women are less successful in their abstinence attempts have been proffered, the observation that women are more likely to experience emergence of depressive symptoms during smoking cessation, a known risk factor for relapse, may be the most important contributor to this sex-specific recidivism. Several lines of evidence suggest that nicotine modulation of GABA may play an important role in this interplay between sex, depression, and smoking recidivism. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT03576768 -
QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt
|
N/A | |
Completed |
NCT04124432 -
Behavioral Pharmacology of Cannabis and Nicotine
|
Phase 1 | |
Enrolling by invitation |
NCT04038515 -
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes
|
Phase 2 | |
Completed |
NCT01223404 -
Nicotinic Modulation of the Default Network
|
N/A | |
Recruiting |
NCT05864586 -
Developing E-liquid Product Standards (Sweet Spot Study)
|
N/A | |
Completed |
NCT05317195 -
Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouch 1.0 Compared to Velo® Ice Cool and Zyn® Cool Mint Mini Dry in Healthy Smokers
|
N/A | |
Withdrawn |
NCT03010995 -
The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
|
Phase 1 | |
Active, not recruiting |
NCT04189146 -
Inner Engineering Yoga Program on Short and Long Term Health Effects (ISHA-Impact): A Longitudinal Study
|
N/A | |
Completed |
NCT05487456 -
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
|
N/A | |
Completed |
NCT03102931 -
Switching to Low Oxidant Content Cigarettes in Adult Smokers
|
N/A | |
Completed |
NCT03134339 -
The Effect of Nicotine Delivery Rate on Reinforcement
|
Early Phase 1 | |
Recruiting |
NCT06346353 -
Substance Consumption, Personality, and Cognitive Functioning of Chess Players
|
||
Completed |
NCT05383508 -
Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes
|
N/A |