Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Status Not yet recruiting

Clinical Trial Summary

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

Clinical Trial Description

The investigators will examine the influence of cooling components of WS-3, WS-23 (synthetic coolants) and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults. Participants will rate the flavor intensity, coolness, sweetness, and irritation/harshness, bitterness experienced using validated rating scales. 66 adult participants (18+ years of age) who are current e-cigarette users will participate in 3 laboratory sessions. Participants will receive 3 e-cigarette that contain cooling flavors and nicotine (59mg/ml nicotine salt) during the sessions. Participants will be randomized to receive one of the 3 menthol conditions (no-menthol, low menthol, high menthol) in combination three WS-3 conditions (no WS-3, low WS-3, high WS-3) and two WS-23 conditions (low WS-23, high WS-23). All participants will be exposed to all fifteen conditions across 3 lab sessions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05932745
Study type	Interventional
Source	Yale University
Contact	Danielle Davis, PhD
Phone	203-974-7607
Email	danielle.davis@yale.edu
Status	Not yet recruiting
Phase	N/A
Start date	November 2024
Completion date	November 2025

View Details

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