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Effects of Varenicline on Smoking Reminders — VSMK  

Nicotine Dependence Clinical Trial

Official title:
Characterizing a Cue-vulnerable Pharmaco-responsive Endophenotype in Smokers

Clinical Trial Summary

Varenicline is the best smoking cessation agent to date; however it is only effective in a subgroup of smokers and is associated with undesirable side effects in other subgroups. To understand the underlying pharmaco-heterogeneity, the proposed project will use perfusion functional magnetic resonance imaging and a functional candidate gene association approach using brain, behavioral, and clinical endpoints in a placebo-controlled study of chronic varenicline administration in smokers. Brain and behavioral responses to smoking cues will be will be significantly greater in 9/10-repeats compared to 10/10-repeats. DAT 9/10-repeat smokers receiving varenicline will have better treatment outcome compared to 10/10-repeats. For the purposes of the clinical trial portion of the study, the change from cigarettes per day at Baseline to the last day of treatment will be reported.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01524627
Study type Interventional
Source University of Pennsylvania
Contact
Status Completed
Phase Phase 2
Start date December 2011
Completion date November 2015
View Details
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