Neural Mechanisms Associated With Risk of Smoking Relapse

Status Active, not recruiting

Clinical Trial Summary

This study will examine how abstinence-induced brain changes contribute to smoking cessation outcomes in treatment-seeking smokers.

Clinical Trial Description

Smoking is the greatest preventable cause of mortality and a significant economic burden. Even with the best available treatments, most smokers relapse within days or weeks after a quit attempt. Nicotine replacement therapy, the most widely used pharmacotherapy, yields end of treatment quit rates of <25% suggesting that managing nicotine withdrawal is not sufficient. To improve quit rates significantly, a more refined mechanistic understanding is needed. Neuroimaging can identify mechanisms underlying behavior change beyond self-report and behavioral measures. Functional magnetic resonance imaging (fMRI) studies show that brief (e.g., 24 hr.) abstinence from smoking produces working memory deficits associated with reduced neural activity in cognitive control circuits and weakened resting state functional connectivity. Neural reactivity to smoking cues also increases risk of relapse, and psychological stress can enhance neural responses to smoking cues and increase smoking intensity. This study will examine how abstinence-induced brain changes contribute to clinical outcomes in treatment-seeking smokers. Using a validated fMRI abstinence challenge paradigm, 200 treatment-seeking smokers will complete two 1-hour pre-treatment fMRI scans: after smoking satiety and after 24 hours of confirmed abstinence. The investigators will examine brain responses during performance of tasks probing working memory, cue reactivity, and stress response as well as resting state functional connectivity. Participants will then set a target quit date, receive smoking cessation counseling, and be monitored for 6 months to assess time to relapse using a validated smoking relapse protocol. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02837510
Study type	Interventional
Source	University of Pennsylvania
Contact
Status	Active, not recruiting
Phase	N/A
Start date	May 2016
Completion date	October 31, 2024

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT02643914` - Control Systems Approach to Predicting Individualized Dynamics of Nicotine Cravings	N/A
Completed	`NCT02153749` - Effects of Brief Training on Craving Regulation	N/A
Recruiting	`NCT05530577` - Effects of Semaglutide on Nicotine Intake	Phase 2
Withdrawn	`NCT05440721` - Clinical Trial of an Innovative Digital Therapeutic for Smoking Cessation With Biochemical Verification	N/A
Completed	`NCT03694327` - Innovative Digital Therapeutic for Smoking Cessation	N/A
Completed	`NCT01944423` - Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine	Early Phase 1
Completed	`NCT01704573` - Nicotinic Receptor Levels After Stopping Smoking	N/A
Active, not recruiting	`NCT01015170` - STOP Study: Effectiveness of Zyban in a Clinical Population	Phase 4
Completed	`NCT03281629` - Circuitry-Guided Smoking Cessation in Schizophrenia	N/A
Recruiting	`NCT06291584` - Effects of Exercises on Functional Capacity	N/A
Withdrawn	`NCT06259630` - Nicotine Virtual Reality Conditioned Place Preference	Phase 4
Completed	`NCT02624284` - tDCS Effects on Resisting Smoking: Dose Ranging Study	N/A
Completed	`NCT02656745` - Clinical Trial of Smoking Cessation Mobile Phone Program	N/A
Completed	`NCT01062932` - Investigation of Cycloserine as a Smoking Cessation Treatment	Phase 1
Completed	`NCT03069482` - Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness	Phase 1
Completed	`NCT02870218` - Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use	Phase 2
Terminated	`NCT01756053` - Effects of ABT-089 on Smoking Abstinence Symptoms and Reward	Phase 2
Completed	`NCT01252966` - Cognitive Training for Nicotine Dependence	N/A
Active, not recruiting	`NCT04946825` - Quit Smoking Study for People Who Use E-Cigarettes	Phase 2
Recruiting	`NCT05434429` - Mobile Health for Problematic Behaviors and Substance Use	N/A