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A Study of Avutometinib for People With Solid Tumor Cancers

Solid Tumor Clinical Trial

Official title:
A Multi-Center Phase I Dose Escalation Study of Avutometinib, a RAF/MEK Clamp, in Pediatric Patients With Refractory or Recurrent Solid Tumors Harboring Activating MAPK Pathway Alterations

Clinical Trial Summary

The purpose of this study is to find out whether avutometinib is a safe treatment for advanced or recurrent solid tumor cancers in children and young adults. Researchers will look for the highest dose of avutometinib that is safe and cause few or mild side effects.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Brain Neoplasms
  • Central Nervous System Neoplasms
  • Central Nervous System Tumor
  • CNS Tumor, Adult
  • CNS Tumor, Childhood
  • CNS Tumors
  • Glioma
  • Low-grade Glioma
  • Neoplasms
  • Nervous System Neoplasms
  • Neuroblastoma
  • Neurofibroma
  • Neurofibroma, Plexiform
  • Neurofibromatoses
  • NF1
  • Optic Pathway Gliomas
  • Plexiform Neurofibroma
  • Primary Brain Tumor
  • Refractory Cancer
  • Solid Carcinoma
  • Solid Tumor
  • Solid Tumor, Adult
Clinical Trial Details
NCT number NCT06104488
Study type Interventional
Source Memorial Sloan Kettering Cancer Center
Contact Sameer Farouk Sait, MD
Phone 212-639-3449
Email faroukss@mskcc.org
Status Recruiting
Phase Phase 1
Start date October 20, 2023
Completion date October 20, 2029
View Details
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