Clinical Trials Logo
  1. Home
  2. Newborn
  3. NCT06368154

Exosome microRNAs as Potential Biomarkers of Metabolic Bone Disease of Prematurity

Newborn Clinical Trial

Official title:
Prospective Cohort Study of Exosomal microRNAs as Biomarkers for Diagnosis and Therapeutic Efficacy Evaluation of Metabolic Bone Diseases in Premature Infants

Clinical Trial Summary

Metabolic bone disease of prematurity (MBDP) is caused by insufficient content of calcium, phosphorus, and organic protein matrix in preterm infants or bone metabolism disorder, which is one of the complications affecting the quality of life of preterm infants. The early symptoms of MBDP are insidious, and there is no unified and clear diagnostic method. The diagnosis is mostly based on typical clinical manifestations and X-ray findings, but at this time, bone mineral density has decreased significantly, so early detection and diagnosis are difficult. Studies have shown that exosomal micrornas have biological characteristics and targeting specificity, and can be used as new molecular diagnostic markers for diseases. Several studies have reported the use of plasma or serum microRNAs as molecular markers for early prediction of bone diseases. In our previous study, we extracted plasma exosomes from preterm infants for high-throughput sequencing of microRNAs, and identified differentially expressed micrornas related to bone metabolism. In this study, exosomes were used as carriers, and digital PCR was used to verify the specificity and sensitivity of plasma exosomal microRNA as biomarkers of MBDP in a large sample size. The above biomarkers were compared and verified before and after treatment in children with MBDP. Further revealing plasma exosomal microRNA as a biological indicator for evaluating the efficacy of MBDP may improve the diagnostic level of MBDP, improve the outcome and prognosis of very low birth weight preterm infants, thereby improving global health and reducing socioeconomic costs.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06368154
Study type Observational
Source Hunan Children's Hospital
Contact yinzhi Y liu, master
Phone 13467532228
Email liuyinzhi0837@163.com
Status Recruiting
Phase
Start date January 1, 2024
Completion date December 31, 2026
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06350084 - Effect of Mother's Touch and Nurse's Therapeutic Touch on Pain Level and Crying Time During Heel Blood Collection N/A
Not yet recruiting NCT04441463 - Simultaneous Study of the Serum Tryptase Level of the Mother and the Child During Childbirth (TryPla) N/A
Not yet recruiting NCT04337229 - Evaluation of Comfort Behavior Levels of Newborns With Artificial Intelligence Techniques N/A
Completed NCT01732978 - Are Parents Privileged Listeners Their Baby ? N/A
Unknown status NCT01029496 - Immediate VS Delayed Cord Clamping on Newborns Phase 1/Phase 2
Recruiting NCT06032494 - Investigating Changes in Vital Signs in Neonates
Completed NCT03690804 - Assessment of Autonomic Co-regulation Between Newborn and Parent During Kangaroo Care Sessions in Neonatal Intensive Care Units N/A
Completed NCT05064683 - The Effect of Facilitated Tucking and White Noise on Stress and Sleep of Newborns in Nasal CPAP N/A
Completed NCT04827849 - Theory of Meleis on Women's Adaptation to Motherhood and Perceptions of Newborn Baby N/A
Not yet recruiting NCT03630575 - Study of Psychoactive Substances in Newborns' Hair Whose Mothers Were Treated and Followed at the Nice University Hospital - New Born Hair Study N/A
Recruiting NCT03109444 - Normative Radiographic Parameters and Growth Curve of Hips Less Than Six Weeks of Gestational Age Using Ultrasound
Not yet recruiting NCT06053931 - The Effect of Music on Neonatal Stress, Mother's Breastfeeding Success and Comfort N/A
Completed NCT04869176 - Effect of Caffeine on Heart Rate Variability in Newborns N/A
Not yet recruiting NCT05109481 - Masks and Visual Preferences in the Newborn
Completed NCT05103800 - Investigation of the Effect of White Noise Listening on Pain and Comfort During Invasive Interventions in Newborns N/A
Completed NCT03047967 - Effects of Prenatal Tobacco Smoke Exposure on Lung Function and Respiratory Epithelium Functionality in Newborns N/A
Completed NCT03969459 - Impact of Exposure to Persistent Organic Pollutants During Pregnancy on the Composition of Breast Milk and Consequences on the Newborn
Not yet recruiting NCT06360159 - Massage for Newborns Receiving Nasal CPAP N/A
Completed NCT06352918 - Peripheral Central Catheter (PICC) Care N/A
Completed NCT05442619 - Developing a Portable Therapeutic Baby Nest for Newborns and Evaluation During Venous Blood Collection N/A