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Nevus, Pigmented clinical trials

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NCT ID: NCT03767439 Withdrawn - Clinical trials for Basal Cell Nevus Syndrome

Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome

Start date: July 2019
Phase: Phase 2
Study type: Interventional

This is a single-arm, phase II study to assess the efficacy of combined SMO and PD-1 inhibition with Vismodegib (SMO inhibitor) and Nivolumab (anti-PD-1 antibody) in BCNS patients (target enrollment of 22 patients), with a primary endpoint of 18-month disease control rate. The purpose of this study is to test the hypothesis that Nivolumab and Vismodegib will improve the percentage of BCNS patients who achieve disease control (defined as total tumor burden <50% of baseline) at 18 months from 50% to 80%. Baseline and on-treatment biopsies will be obtained to characterize the immune effects of combined SMO and PD-1 inhibition.

NCT ID: NCT02473874 Withdrawn - Melanocytic Nevus Clinical Trials

Comparison Imaging System Between Spatially Modulated Quantitative Spectroscopy and Skin Spect Dermoscopy

Start date: June 2015
Phase:
Study type: Observational

The purpose of this study is to obtain skin spectroscopic data from two imaging systems. Comparison groups: - Skin Spect dermoscope - Spatially modulated quantitative spectrometer