Neutropenia Clinical Trial
Official title:
A Prospective, Randomized, Open Label Study of Piperacillin/Tazobactam Versus Imipenem/Cilastin for Empirical Therapy of Febrile Patients With Neutropenia After Hematopoietic Stem Cell Transplantation
Neutropenia is very common in patients received hematopoietic stem cell transplantation,
with median duration of about 14 days. In 2010 update, IDSA recommended
Piperacillin/tazobactam as first-line mono-therapy for febrile patients with neutropenia of
high risk. In china, the data of piperacillin/tazobactam for febrile neutropenia after
hematopoietic stem cell transplantation is very limited.
The current study will evaluate the efficacy of piperacillin/tazobactam compared with
imipenem/cilastatin for febrile neutropenia after transplantation.
1. Swab culture (skin, pharyngeal, nasal, anus) when administered into laminar flow room
after transplantation.
2. Randomize the febrile patients into 2 groups.
3. Therapy group receive piperacillin/tazobactam, 4.5g q6h iv. Control group receive
imipenem/cilastatin, 0.5g q6h. Duration will be 5-10 days.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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