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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT02918032
Other study ID # TRICVD1315
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 2014
Est. completion date March 2025

Study information

Verified date November 2023
Source Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Contact Kenichi Hirano, MD, Ph.D
Phone +81-6-6872-8215
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study aims to understand the state of onset of NLSD(neutral lipid storage disease) / TGCV(triglyceride deposit cardiovasculopathy) worldwide, background information of affected patients, and natural history of the disease, as well as exploring the prognostic factors and assessing the efficacy of disease-specific treatment.


Description:

Since NLSD is a rare disease, its clinical manifestation and clinical course have not been sufficiently clarified. Also, the number of patients in each country is limited. As such, it is considered difficult to fully investigate this disease without international collaboration. Therefore, we have established the International Registry of NLSD / TGCV. Also, all patients with Jordans' anomaly of peripheral polymorphonuclear leukocytes are established as the subjects of entry when starting the registry, to allow entry of patients with NLSD due to genes other than mutations of ATGL and CGI-58 genes. Time Perspective:This study is both Prospective (registering patients who are diagnosed with NLSD / TGCV) and Retrospective (registering only the medical record of previous patients).


Recruitment information / eligibility

Status Recruiting
Enrollment 120
Est. completion date March 2025
Est. primary completion date March 2025
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Patients who are diagnosed with NLSD / TGCV Exclusion Criteria: - None

Study Design


Locations

Country Name City State
Austria University of Graz Graz Steiermark
China Peking University First Hospital Beijing Beijing
France Pitié-Salpêtrière Hospital Paris
Germany Ludwig-Maximilians University Munich Bayern
Italy Catholic University Milano Lombardia
Italy University of Padova Padova Veneto
Italy A.C.O. San Filippo Neri Hospital Rome Lazio
Italy Sapienza University of Rome Rome Lazio
Japan National Center of Neurology and Psychiatry Kodaira-city Tokyo
Japan Graduate School of Osaka University Suita-city Osaka-prefecture
Netherlands Maastricht University Maastricht Limburg
United Kingdom Harefield Hospital Harefield London
United Kingdom New Castle University Newcastle upon Tyne Tyne And Wear
United States Columbia University New York New York
United States Stanford University Stanford California

Sponsors (1)

Lead Sponsor Collaborator
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan

Countries where clinical trial is conducted

United States,  Austria,  China,  France,  Germany,  Italy,  Japan,  Netherlands,  United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Period from the diagnosis of NLSD / TGCV to death from any cause This is the period from the date of diagnosis of NLSD / TGCV to the date of death from any cause. The last date of confirmation of survival will be used as the cut-off date for living patients and patients who are lost to follow-up. 5 years
Secondary Serum CK(Creatine Kinase) level Evaluating the serum CK level by measuring 5 years
Secondary Serum BNP(B-type Natriuretic Peptide) level Evaluating serum BNP level by measuring 5 years
Secondary Serum AST(Aspartate transaminase) level Evaluating serum AST level by measuring 5 years
Secondary Serum ALT(Alanine transaminase) level Evaluating serum ALT level by measuring 5 years
Secondary Serum TG level Evaluating serum TG level by measuring 5 years
Secondary Plasma glucose level Evaluating plasma glucose level by measuring 5 years
Secondary HbA1c Evaluating HbA1c by measuring 5 years
Secondary TSH(thyroid-stimulating hormone) Evaluating TSH by measuring 5 years
Secondary Free T4 Evaluating Free T4 by measuring 5 years
Secondary Ichthyosis Presence / Absence of Ichthyosis within 5 years 5 years
Secondary Jordans' anomaly Presence / Absence of Jordans' anomaly within 5 years 5 years
Secondary Neurosensory disorders Presence / Absence of neurosensory disorders 5 years
Secondary Mental retardation Presence / Absence of mental retardation 5 years
Secondary Hearing loss Presence / Absence of hearing loss 5 years
Secondary Skeletal muscle (Musculoskeletal symptoms) Presence / Absence of musculoskeletal symptoms 5 years
Secondary Skeletal muscle (Muscle weakness) Presence / Absence of muscle weakness 5 years
Secondary Barthel Index Evaluating activities of daily living by Barthel Index 5 years
Secondary Clinical findings of Heart Presence / Absence of cardiac symptoms 5 years
Secondary Clinical findings of Liver Presence / Absence of hepatomegaly 5 years
Secondary Clinical findings of Pancreas Presence / Absence of diabetes mellitus 5 years
Secondary Manual muscle test Evaluating muscles by Manual muscle test 5 years
Secondary Muscle biopsy To evaluate lipid involvement and deposition 5 years
Secondary Myocardial biopsy To evaluate lipid involvement and deposition 5 years
Secondary Skin biopsy To evaluate lipid involvement and deposition 5 years
Secondary Respiratory function test Evaluating muscles by Respiratory function test 5 years
Secondary 6-minute walk distance Evaluating heart function by 6-minute walk distance 5 years
Secondary Treadmill endurance time Evaluating heart function by treadmill endurance time 5 years
Secondary Cardiopulmonary exercise test Evaluating heart function by cardiopulmonary exercise test 5 years
Secondary Skeletal muscle(CT) Evaluating skeletal muscle using CT 5 years
Secondary Skeletal muscle(MRI) Evaluating skeletal muscle using MRI 5 years
Secondary Skeletal muscle(electromyogram) Evaluating skeletal muscle using electromyogram 5 years
Secondary Fatty liver(ultrasonography) Evaluating fatty liver by ultrasonography 5 years
Secondary Thyroid(ultrasonography) Evaluating thyroid by ultrasonography 5 years
Secondary Echocardiogram Measuring echocardiogram 5 years
Secondary Cardiac CT Measuring cardiac CT 5 years
Secondary Cardiac MRI Measuring cardiac MRI 5 years
Secondary Coronary angiography Measuring coronary angiography 5 years
Secondary Electrocardiogram Measuring electrocardiogram 5 years
Secondary Holter monitoring Measuring holter monitoring 5 years
Secondary BMIPP scintigram Evaluating myocardial lipolysis 5 years
See also
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