Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Period from the diagnosis of NLSD / TGCV to death from any cause |
This is the period from the date of diagnosis of NLSD / TGCV to the date of death from any cause. The last date of confirmation of survival will be used as the cut-off date for living patients and patients who are lost to follow-up. |
5 years |
|
Secondary |
Serum CK(Creatine Kinase) level |
Evaluating the serum CK level by measuring |
5 years |
|
Secondary |
Serum BNP(B-type Natriuretic Peptide) level |
Evaluating serum BNP level by measuring |
5 years |
|
Secondary |
Serum AST(Aspartate transaminase) level |
Evaluating serum AST level by measuring |
5 years |
|
Secondary |
Serum ALT(Alanine transaminase) level |
Evaluating serum ALT level by measuring |
5 years |
|
Secondary |
Serum TG level |
Evaluating serum TG level by measuring |
5 years |
|
Secondary |
Plasma glucose level |
Evaluating plasma glucose level by measuring |
5 years |
|
Secondary |
HbA1c |
Evaluating HbA1c by measuring |
5 years |
|
Secondary |
TSH(thyroid-stimulating hormone) |
Evaluating TSH by measuring |
5 years |
|
Secondary |
Free T4 |
Evaluating Free T4 by measuring |
5 years |
|
Secondary |
Ichthyosis |
Presence / Absence of Ichthyosis within 5 years |
5 years |
|
Secondary |
Jordans' anomaly |
Presence / Absence of Jordans' anomaly within 5 years |
5 years |
|
Secondary |
Neurosensory disorders |
Presence / Absence of neurosensory disorders |
5 years |
|
Secondary |
Mental retardation |
Presence / Absence of mental retardation |
5 years |
|
Secondary |
Hearing loss |
Presence / Absence of hearing loss |
5 years |
|
Secondary |
Skeletal muscle (Musculoskeletal symptoms) |
Presence / Absence of musculoskeletal symptoms |
5 years |
|
Secondary |
Skeletal muscle (Muscle weakness) |
Presence / Absence of muscle weakness |
5 years |
|
Secondary |
Barthel Index |
Evaluating activities of daily living by Barthel Index |
5 years |
|
Secondary |
Clinical findings of Heart |
Presence / Absence of cardiac symptoms |
5 years |
|
Secondary |
Clinical findings of Liver |
Presence / Absence of hepatomegaly |
5 years |
|
Secondary |
Clinical findings of Pancreas |
Presence / Absence of diabetes mellitus |
5 years |
|
Secondary |
Manual muscle test |
Evaluating muscles by Manual muscle test |
5 years |
|
Secondary |
Muscle biopsy |
To evaluate lipid involvement and deposition |
5 years |
|
Secondary |
Myocardial biopsy |
To evaluate lipid involvement and deposition |
5 years |
|
Secondary |
Skin biopsy |
To evaluate lipid involvement and deposition |
5 years |
|
Secondary |
Respiratory function test |
Evaluating muscles by Respiratory function test |
5 years |
|
Secondary |
6-minute walk distance |
Evaluating heart function by 6-minute walk distance |
5 years |
|
Secondary |
Treadmill endurance time |
Evaluating heart function by treadmill endurance time |
5 years |
|
Secondary |
Cardiopulmonary exercise test |
Evaluating heart function by cardiopulmonary exercise test |
5 years |
|
Secondary |
Skeletal muscle(CT) |
Evaluating skeletal muscle using CT |
5 years |
|
Secondary |
Skeletal muscle(MRI) |
Evaluating skeletal muscle using MRI |
5 years |
|
Secondary |
Skeletal muscle(electromyogram) |
Evaluating skeletal muscle using electromyogram |
5 years |
|
Secondary |
Fatty liver(ultrasonography) |
Evaluating fatty liver by ultrasonography |
5 years |
|
Secondary |
Thyroid(ultrasonography) |
Evaluating thyroid by ultrasonography |
5 years |
|
Secondary |
Echocardiogram |
Measuring echocardiogram |
5 years |
|
Secondary |
Cardiac CT |
Measuring cardiac CT |
5 years |
|
Secondary |
Cardiac MRI |
Measuring cardiac MRI |
5 years |
|
Secondary |
Coronary angiography |
Measuring coronary angiography |
5 years |
|
Secondary |
Electrocardiogram |
Measuring electrocardiogram |
5 years |
|
Secondary |
Holter monitoring |
Measuring holter monitoring |
5 years |
|
Secondary |
BMIPP scintigram |
Evaluating myocardial lipolysis |
5 years |
|