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Neurotrophic Keratopathy clinical trials

View clinical trials related to Neurotrophic Keratopathy.

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NCT ID: NCT06412718 Not yet recruiting - Rare Diseases Clinical Trials

Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies

Start date: May 2024
Phase:
Study type: Observational

The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with inflammation/pain. Moreover, the following alternative targets are: VEGF, PAX6 and pro-inflammatory cytokine. The following procedures are performed specifically for the study: samples of blood, tear fluid and impression cytology. Precisely during the ophthalmological exam performed according to normal clinical practice (uncorrected visual acuity, best spectacle corrected visual acuity, corneal topography, corneal pachymetry and the slit lamp pictures) investigator's team collect the samples of blood, tear fluid and impression cytology to evaluate the goal of the study.

NCT ID: NCT06331910 Not yet recruiting - Clinical trials for Neurotrophic Keratopathy

Efficacy and Safety of Topical Insulin for Neurotrophic Corneal Ulcers

Start date: April 1, 2024
Phase: Phase 4
Study type: Interventional

To evaluate Safety and efficacy of topical insulin in treatment of neurotrophic corneal ulcers