Serum Neurofilament Light (NfL) as a Marker for Brain Injury in

Clinical Trial Summary

The investigators propose that immune effector cell-associated neurotoxicity syndrome (ICANS) is predicated upon the early loss of blood brain barrier (BBB) integrity with subsequent monocyte infiltration leading to cross-activation of native glial cells. Glial overstimulation leads to neuroinflammation, synaptic dysfunction, and ultimately neuronal injury.

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NCT number	NCT04614987
Study type	Observational
Source	Washington University School of Medicine
Contact
Status	Terminated
Phase
Start date	February 25, 2021
Completion date	September 13, 2023

Serum Neurofilament Light (NfL) as a Marker for Brain Injury in Individuals Undergoing Chimeric Antigen Receptor-modified T Therapy

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms