Neuroregulation of Breathing Clinical Trial
Official title:
Effects of Abnormal Respiratory Mechanics and Assisted Mechanical Ventilation on Neuro Regulation of Respiration
Due to recent technological improvements, it is now possible to record the electrical
activity of the diaphragm (Eadi), a direct expression of the central nervous system
respiratory center activity. By providing a relatively easy-to-use technique to record Eadi
the NAVA (Neurally Adjusted Ventilatory Assist) technology offers a new opportunity to
explore the effects of various interventions on neural inspiratory activity in human
subjects during spontaneous and assisted ventilation both for normal and simulated abnormal
respiratory mechanics.
The main aim of this project is to measure and compare the components of Eadi signal, the
direct reflect of the respiratory centers activity, under various conditions of normal and
simulated altered respiratory mechanics (either obstructive or restrictive respiratory
mechanics° in order to better understand the neuroregulation of breathing. The second aim of
the present project is to perform a similar analysis regarding the effects of various modes
(Pressure Support and NAVA) and various levels of assisted ventilation both in case of
normal and abnormal respiratory mechanics. Based on the information recorded on Eadi and
flow and pressure signals, the last aim of this project is to correlate Eadi and pneumatic
derived parameters both during spontaneous breathing and assisted ventilation.
Practically, by using the NAVA recording technology, the investigators will perform a
physiological study on normal volunteers to explore the effects of normal and simulated
abnormal respiratory mechanics on Eadi, flow and pressure signals (airway, oesophageal and
transdiaphragmatic pressures) in order to better understand the neuroregulation of
breathing. Thirty healthy volunteers with documented normal lung function tests will be
included in the study (obstructive respiratory mechanics will be simulated in 15 healthy
volunteers and respiratory mechanics will be simulated in 15 healthy volunteers).
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science