Study of the Hemispheric Specialization for Language in Subjects With Neuropsychiatric Disorders Compared to Control Subjects

Neuropsychiatric Disorders Clinical Trial

— BIP  

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02523742
• Other study ID #: 05-097
• Status: Completed
• Phase: N/A
• Start date: November 2005
• Est. completion date: April 23, 2015

Study information

• Verified date: August 2015
• Source: University Hospital, Caen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Recently, we have shown functional resonance imaging (fMRI) that variations in signal induced by a language task were significantly lower in a semantic region of the left hemisphere (comprised of that part pars triangularis of the inferior frontal gyrus and the temporal gyri medium and angular) in schizophrenic patients compared with controls matched for age, sex, level of education and handedness.

Investigators wish to test the hypothesis that functional modification of the hemispherical specialization is specific language and also specific for schizophrenia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 152
• Est. completion date: April 23, 2015
• Est. primary completion date: November 19, 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients under 65 years

• Schizophrenics, bipolar or schizoaffective (DSM IV)

• Patients who signed informed consent

Exclusion Criteria:

• Women with childbearing potential without effective contraception or positive pregnancy test.

• Contra-indications to fMRI

Related Conditions & MeSH terms

• Neuropsychiatric Disorders

Intervention

Device:
• IMRf

Other:
• language task and a reference task (rest and Tamil)

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Caen

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	variation in signal (SPM99) during a language task compared to a reference task (rest or Tamil) in fMRI in anatomical regions of interest		baseline