Neuroplasticity Clinical Trial
Official title:
Effects of Non-invasive Brain Stimulation Methods in Experimentally Induced Pain
Corticomotor excitability, pain sensitivity, descending pain control and somatosensory evoked
potentials (SEPs) is often altered in acute and chronic pain.
Topical capsaicin generates stable, long-lasting hyperalgesia and ongoing tonic pain in
healthy participants, which significantly inhibits corticomotor excitability in the primary
motor cortex (M1).
Recent studies (by Fischer et al 2017) indicated that multifocal Transcranial Direct Current
Stimulation (tDCS) administered to brain regions linked to the resting state motor network
(network-tDCS) could enhance corticomotor excitability in healthy participants compared to
single site M1-tDCS.
It remains unknown whether network-tDCS has also the potential to modulate the inhibitory
effects on motor cortex excitability, pain sensitivity, descending pain control and SEPs
associated with prolonged pain
To date, pain modulation to M1 rs-network tDCS during 8% capsaicin induced pain has not been
assessed (Mylius, Borckardt and Lefaucheur, 2012). Further, it is unknown how multichannel
tDCS acts on tonic cutaneous pain for approximately 24 hours.
The main objective of these projects are to study and characterize quantitatively the effects
of multichannel tDCS in the development of prolonged pain.
It is hypothesized that multichannel tDCS of left M1 resting-state network will reduce the
severity of experimentally prolonged pain over the m. first dorsal interosseous (FDI), will
increase descending pain control, might possibly increase pain thresholds and simultaneously
will modulate the peak-to-peak amplitude of SEPs to electrical painful stimulation. Further,
it is hypothesized that descending pain modulation of M1 tDCS will be related to interference
with the suppression of cortical excitability
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