Neuromodulation With Low Frequency-Pulsed Electromagnetic Fields

Status Completed

Clinical Trial Summary

Non-depolarizing magnetic fields, like Low Frequency-Pulsed Electromagnetic Fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels on cellular membranes. Recently, the CTU Mega 20 device was presented as a molecular accelerator, using energy up to 200 Joules and providing high-power (2 Tesla) pulsating fields with a water-repulsive (diamagnetic) action and tissue biostimulation. The investigators tested the hypothesis that LF-PEMFs could modulate long-term corticospinal excitability in healthy brains by applying CTU Mega 20®. Ten healthy subjects without known neurological and/or psychiatric diseases entered the study. A randomized double-blind sham-controlled crossover design was employed, recording TMS parameters (amplitude variation of the motor evoked potential as index of cortical excitability perturbations of the motor system) before (pre) and after (post +0, +15, +30 min) a single CTU Mega 20 session on the corresponding primary right-hand motor area, using a real (magnetic field = 2 Tesla; intensity = 90 J; impulse frequency = 7Hz; duration = 15 minutes) or sham device. A two-way repeated measures ANOVA with TIME (pre, post +0, +15, +30 min) and TREATMENT (real vs sham stimulation) as within-subjects factor was applied.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Electromagnetic Fields
Neuronal Plasticity
Transcranial Magnetic Stimulation

Clinical Trial Details

NCT number	NCT03537469
Study type	Interventional
Source	Azienda Ospedaliera Spedali Civili di Brescia
Contact
Status	Completed
Phase	Early Phase 1
Start date	March 10, 2016
Completion date	July 10, 2016

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