Neuronal Plasticity Clinical Trial
Official title:
Multimodal Associations of Human Brain Plasticity Investigated With Simultaneous PET/MR Imaging
Background: Neuronal plasticity is the brain's ability to continuously adapt to experiences
and learning of new skills. Although this affects multiple characteristics of the brain such
as structure, function and metabolism, direct interactions between these aspects are largely
missing.
Aim: Using recent advancements in neuroimaging we aim to identify novel relationships how
neuronal plasticity is related across these characteristics.
Design: 40 healthy subjects will undergo two simultaneous PET/MR measurements at baseline and
after 4 weeks. During the measurements a cognitively challenging task will be performed and
the training group (20 subjects) will practice during the 4-week period.
Implications: We combine simultaneous PET/MR and novel task-specific PET imaging to study
brain metabolism, structure and function in a single measurement session. This provides
optimal sensitivity for assessment of multimodal neuroplasticity associations. Knowledge how
cognitive training affects multiple characteristics of the brain will also increase our
understanding of disorders like depression, dementia and brain injuries, since these are
diagnosed with cognitive evaluations. Considering the vast usage of the applied imaging
procedures in diagnosis and therapy monitoring, the thorough investigation of multimodal
associations offers benefit for the interpretability of neuroimaging in clinical routine.
Methodological details: Each subject will undergo two PET/MR examinations. Imaging will include PET as well as acquisition of structural and functional MRI. Task-specific glucose metabolism will be quantified with the radioligand [18F]FDG. Gray matter volume and white matter microstructure will be assessed with T1-weighted and diffusion weighted MRI, respectively. Functional imaging will focus on functional connectivity during rest and task as well as cerebral blood flow as acquired with ASL. ;
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