Clinical Trials Logo

Clinical Trial Summary

Neuromuscular scoliosis are caused by a disorder of the brain, spinal cord or muscular system and often progressive at early age. Conservative treatment is not sufficient to maintain trunk and pelvic balance, and surgical treatment is frequently required. Early definitive spine fusion has the disadvantage of cessation of trunk growth with concomitant effects on lung development. Growth preserving spine surgeries are increasingly used but with high complication rates. The orthopaedic team at Necker Hospital Enfants maladies, Paris, France has developed an innovative fusionless surgery based on a bipolar spine construct, performed by a minimally invasive approach. The first 100 patients operated on with this technique had an average follow-up of 6.5 years. No arthrodesis, initially planned in adolescence, was necessary thanks to the stability of the correction of the deformities even after skeletal maturation. The main objective of the study was to analyze the progressive spinal stiffening, using muscle and disc elastography, in neuromuscular patients instrumented with this bipolar construct.


Clinical Trial Description

Neuromuscular scoliosis is related to muscle tone abnormalities with a prognosis worsen by damage to the axial and respiratory muscles. The classic treatment for these scoliosis consists of conservative treatment (physiotherapy, bracing), followed by arthrodesis in adolescence. Arthrodesis consists of a global posterior spinal fusion, with a high risk of septic and hemorrhagic complications. In cases of early and rapidly progressive deformities, fusionless techniques allow the preservation of growth while waiting for arthrodesis. However, these techniques have a high rate of complications, particularly of mechanical and infectious origin, which led the orthopedic team at Necker Hospital, Paris, France to develop an innovative technique. This technique is based on bipolar construct, performed by a minimally invasive approach. The first 100 patients operated on have an average follow-up of 6.5 years. No arthrodesis, initially planned in adolescence for these patients, was necessary, thanks to the stability of the correction even after skeletal maturation. The main objective of the study was to analyze the progressive spinal stiffening, using muscle and disc elastography, in neuromuscular patients instrumented with this bipolar construct. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04969770
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact
Status Active, not recruiting
Phase N/A
Start date January 11, 2022
Completion date July 2024

See also
  Status Clinical Trial Phase
Not yet recruiting NCT06023043 - Postoperative Steroid Use in Adolescent Idiopathic Scoliosis and Neuromuscular Scoliosis Patients Phase 4
Completed NCT04021784 - Limited-efficacy Testing of SDS and NEMOST for Early Onset Neuromuscular Scoliosis N/A
Recruiting NCT04764812 - Determination of Risk Factors and Awareness Associated With Development of Neuromuscular Scoliosis
Completed NCT01645111 - An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Phase 2/Phase 3
Not yet recruiting NCT06367933 - Mini-invasive Spine Surgery for Neuromuscolar Scoliosis N/A
Completed NCT03000010 - Wound Vac Bandage Comparison After Spinal Fusion N/A
Completed NCT03863496 - Efficacy of Surgical Treatment by Different Pedicle Screw Systems in Pediatric Neuromuscular Spinal Deformity N/A
Recruiting NCT06042699 - Scoliosis Iron Supplementation Study N/A
Recruiting NCT05281757 - Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Complex
Recruiting NCT05071144 - Spine Procedures Assisted With RoboTics And Navigation
Completed NCT04012112 - The Effect of Flexible Thoracolumbar Brace on Spinal Alignment, Pain and Quality of Life in Subjects With Neuromuscular Scoliosis N/A
Terminated NCT02670798 - Thromboelastography Transfusion Protocol for Pediatric Neuromuscular Scoliosis Surgery N/A
Completed NCT03862625 - Seating System for Scoliosis in Non-ambulatory Children With Cerebral Palsy: A Pilot Randomized Controlled Trial N/A