The Influence of High Impact Exercise on Musculoskeletal Health in Older Men

Neuromuscular Function Clinical Trial

— Hiphop  

Official title:

The Influence of High Impact Exercise on Musculoskeletal Health in Older Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02007460
• Other study ID #: R10-P1
• Status: Completed
• Phase: N/A
• First received: November 27, 2013
• Last updated: December 5, 2013
• Start date: January 2010
• Est. completion date: January 2012

Study information

• Verified date: December 2013
• Source: Loughborough University
• Contact: n/a
• Is FDA regulated: No
• Health authority: UK: National Research Ethics ServiceUK: Loughborough University Ethical Advisory Committee
• Study type: Interventional

Clinical Trial Summary

Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: January 2012
• Est. primary completion date: January 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 65 Years to 80 Years

Eligibility

Inclusion Criteria:

• Healthy community dwelling men of white european origin

Exclusion Criteria:

• BMI >30 kg/m2

• History of strength training or recently ( previous 12 months) doing moderate physical activity (weight bearing, high impact)

• Recent ( previous 12 months) or current medical or surgical problems likely to affect bone metabolism or provide contraindications to high impact exercise, balance or neuromuscular function

• Any previous or existing lower back or limb problems that could be exacerbated by undertaking high impact exercise

• Any history of diagnosed or symptomatic diseases likely to influence strength, power, bone or habitual activity (including osteomalacia or impaired liver/renal function and locomotor disease, hypertension) that influences bone or muscle or precludes exercise

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Bone Strength
• Neuromuscular Function

Intervention

Behavioral:
• Exercise
multidirectional unilateral hopping exercise

Locations

Country	Name	City	State
United Kingdom	Loughborough University	Loughborough	Leicestershire

Sponsors (3)

Lead Sponsor	Collaborator
Loughborough University	Derby Hospitals NHS Foundation Trust, University Hospitals Leicester NHS Trust, UK

Country where clinical trial is conducted

United Kingdom, 

References & Publications (1)

Allison SJ, Folland JP, Rennie WJ, Summers GD, Brooke-Wavell K. High impact exercise increased femoral neck bone mineral density in older men: a randomised unilateral intervention. Bone. 2013 Apr;53(2):321-8. doi: 10.1016/j.bone.2012.12.045. Epub 2013 Jan — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Serum 25 hydroxy vitamin D		baseline	No
Other	Change in body fat content		baseline, 12 months	No
Other	change in energy intake (MJ/d)		baseline, 12 months	No
Other	change in calcium intake		baseline, 12 months	No
Primary	Change in femoral neck bone mineral density		baseline, 12 months	No
Secondary	Change in cortical bone mineral content		baseline, 12 months	No
Secondary	Change in trabecular bone mineral content		baseline, 12 months	No
Secondary	Change in ground reaction force during hopping		baseline, 6 months, 12 months	No
Secondary	Change in electromyography of quadriceps during hopping		baseline, 6 months	No
Secondary	Change in postural sway amplitude (mm)		baseline, 6 months	No
Secondary	Change in leg press strength		baseline, 6 months	No
Secondary	Change in maximal isometric knee extensor strength		baseline, 6 months	No
Secondary	Change in tendon stiffness		baseline, 6 months	No