Investigation to the Mechanism of the Neuroplastic Modulation in Central

Status Completed

Clinical Trial Summary

Tinnitus is the awareness of sound or noise in the absence of acoustic stimulation. No definite therapeutic strategy of tinnitus has been developed yet. The current theory of tinnitus is the plasticity theory of neurophysiology model. Although acupuncture has its role in tinnitus treatment, its actual role still remains to be elucidated. Acupuncture has been proposed to induce the development of neuroplasticity. The aim of this project is to undergo a comprehensive investigation to the central auditory effect and the therapeutic effects of acupuncture in tinnitus. According the results of the preliminary studies, the objective auditory measurement and subjective tinnitus perception will be analyzed in tinnitus patients before and after acupuncture.

Clinical Trial Description

Hearing loss is a common sensory deficit in human beings. Besides communication handicaps, hearing loss may associate with niggling tinnitus symptoms. Tinnitus is the awareness of sound or noise in the absence of acoustic stimulation. Tinnitus may cause bothersome problems in cognition, mood, or psychosocial behaviour and constitute a significant portion in the outpatient clinics of ENT practice. No definite therapeutic strategy of tinnitus has been developed yet. The current theory of tinnitus is the plasticity theory of neurophysiology model. According to this theory, several neuromodulation methods have been proposed such as repetitive transcranial magnetic stimulation (rTMS) or vagus nerve stimulation (VNS). Although acupuncture has its role in tinnitus treatment, its actual role still remains to be elucidated. Acupuncture has been proposed to induce the development of neuroplasticity. There are still few thorough researches to investigate the neurophysiological events after acupuncture. The aim of this project is to undergo a comprehensive investigation to the central auditory effect and the therapeutic effects of acupuncture in tinnitus. According the results of the preliminary studies, the objective auditory measurement and subjective tinn itus perception will be analyzed in tinnitus patients before and after acupuncture. The ultimate results of this project will clarify the basic central auditory effects of acupuncture and provide a potential for translational application of acupuncture to treat the common tinnitus patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05591807
Study type	Observational
Source	China Medical University Hospital
Contact
Status	Completed
Phase
Start date	July 2, 2019
Completion date	September 30, 2019

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05963542` - Efficacy of Online Acceptance and Commitment Therapy and Sound Therapy for Patients With Tinnitus and Insomnia	N/A
Recruiting	`NCT04987502` - Virtual Reality and Subjective Tinnitus	N/A
Recruiting	`NCT04404439` - Treatment of Tinnitus With Migraine Medications	Phase 4
Recruiting	`NCT05533840` - Establishment and Application of a New Imaging System for Otology Based on Ultra-high Resolution CT
Completed	`NCT03552302` - Effects of Yoga Exercise on Participates With Tinnitus
Enrolling by invitation	`NCT02617953` - Objective Diagnosis Method and Efficacy of Repetitive Transcranial Magnetic Stimulation as a Treatment for Tinnitus	N/A
Withdrawn	`NCT01663467` - Efficacy of Internet and Smartphone Application-delivered Tinnitus Retraining Therapy	N/A
Completed	`NCT02269839` - A Feasibility Study Assessing the Effectiveness of rTMS in Tinnitus	N/A
Completed	`NCT02974543` - Somatosensory Stimulation to Alleviate Tinnitus	N/A
Completed	`NCT01929837` - Tinnitus rTMS 2013	N/A
Completed	`NCT01857661` - The Influence of the Sound Generator Combined With Conventional Amplification for Tinnitus Control: Blind Randomized Clinical Trial	N/A
Completed	`NCT01927991` - Internet-based Self-help for Tinnitus: The Role of Support	N/A
Completed	`NCT01480193` - New Therapy for Patients With Severe Tinnitus	N/A
Terminated	`NCT01412918` - Inhibitor Masking Device & Sodium Channel, Voltage Gated, Type IX Alpha Subunit (SCN9) Gene Expression	N/A
Completed	`NCT00748475` - Countering Stimulus-Induced Alpha-Desynchronization to Treat Tinnitus	N/A
Completed	`NCT00371436` - Progressive Intervention Program for Tinnitus Management	N/A
Completed	`NCT00733044` - Cost-effectiveness of Multidisciplinary Management of Tinnitus	N/A
Active, not recruiting	`NCT05518682` - Assessment of Bimodal Stimulation Device Compliance and Satisfaction in Individuals With Tinnitus	N/A
Recruiting	`NCT05212298` - Effects of Herbal Sleep Formula on Patients With Insomnia and Tinnitus	N/A
Completed	`NCT06025097` - Intra-Tympanic Steroid With PRP Combination in Sensorineural Hearing Loss and Tinnitus.	Early Phase 1

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Investigation to the Mechanism of the Neuroplastic Modulation in Central Auditory Tract

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms