HIERARCHY OF VISION

Neurologic Signs Clinical Trial

— HIERARCHY  

Official title:

Hierarchical Processing of Visual Movement

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03905616
• Other study ID #: 69HCL18_0933
• Secondary ID: 2019-A00465-52
• Status: Withdrawn
• Phase: N/A
• Start date: July 22, 2019
• Est. completion date: February 17, 2021

Study information

• Verified date: February 2021
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Little is known about the exact role of feedback in cortical processing. Hypotheses on its function range from attentional control to the transmission of Bayesian priors in the interpretation of sensory events, such as in the theory of Predictive Coding. Recent advances in identification of functional signatures of feedback and feedforward signal, as well as additional techniques based on causal relations in signal processing open a unique methodology for probing such processes in awake and behaving organisms and testing these theories and more generally the hierarchical processing between cortical areas. The objective of this project is to study feedback and feedforward relations and localization in the well established pathways between cortical areas V1 and Medial Temporal (MT) that have been implicated in early integration processes in motion perception.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: February 17, 2021
• Est. primary completion date: February 17, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Aged between 18 and 40 years old
• Affiliated to a social security scheme
• Be right-handed
• Have signed the informed consent

Exclusion Criteria:

• Subjects with a neurological or psychiatric history
• Subjects with visual disturbances not corrected
• Pregnant, lactating or childbearing women without contraception.
• Persons under guardianship, trusteeship or any other administrative or judicial measure of deprivation of rights or liberty, as well as adults protected by law.
• Participants refusing to be informed of the results of the medical examination.
• Participants refusing to be informed of the possible detection of an anomaly.
• Volunteers with contraindications to the MRI examination: people using a pacemaker or an insulin pump, persons wearing a metal prosthesis or an intracerebral clip as well as claustrophobic subjects, neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign body ocular or cerebral close to the nerve structures, agitation of the subject (non-cooperating or agitated subjects), ventriculoperitoneal neurosurgical bypass valves, dental apparatus.

Related Conditions & MeSH terms

• Neurologic Manifestations
• Neurologic Signs

Intervention

Device:
• functional Magnetic Resonance Imaging
In a 2-hour session, the subject we be shown different control and experimental conditions (all being visual stimuli) in perceptive tasks.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Non-invasive Blood oxygenation level dependent (BOLD) fMRI activity	Blood oxygenation level dependent (BOLD) imaging is the standard technique used to generate images in fMRI studies, and relies on regional differences in cerebral blood flow to delineate regional activity. This non-invasive technic is not inducing any particular risk. The non invasive BOLD fMRI activity will be recorded in healthy subjects during a task of visual perception.	At inclusion