Optic Nerve Sheath Diameter, Carotid Duplex and Transcranial Duplex as a Prognostic Factor

Neurologic Dysfunction Clinical Trial

Official title:

Optic Nerve Sheath Diameter, Carotid Duplex and Transcranial Duplex as a Prognostic Predicting Factor in Post-cardiac Arrest Patients

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04510363
• Other study ID #: 201911027RINC
• Status: Recruiting
• Start date: December 17, 2019
• Est. completion date: December 16, 2023

Study information

• Verified date: December 2023
• Source: National Taiwan University Hospital
• Contact: Wan-Ching Lien, PhD
• Phone: +886-223123456
• Email: wanchinglien[@]ntu.edu.tw
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Optic nerve sheath diameter (ONSD) had been proved to be associated with increased intracranial pressure and can be used as one of the prognostic factors in cardiac arrest patients. It is simple, quick and can be measured repeatedly. Carotid duplex and transcranial duplex(TCD) provide rapid, noninvasive, real-time measures of cerebrovascular function. It can be used to assess the vascular territory by measuring blood flow, and to evaluate factors include brain perfusion, plaque morphology, and patency of intracranial collaterals. Hence, it could act as a crucial role in neuroprognosis in post-arrest patients. In this study, the investigator aimed to analyze the ONSD diameters, ONSD/external transverse diameter (ETD) ratio, carotid duplex and transcaranial duplex parameters in different stages of post-cardiac arrest care, demographic characteristics and resuscitation information with the neurological outcome of post-cardiac arrest patients. The ONSD diameter, and ONSD/ETD ratio were compared with age-, and sex-matched normal volunteers.

Description:

Prediction of the neurological outcome in resuscitated post-cardiac arrest patients is important to tailor appropriate management plans. Brain imaging, electrophysiological evaluations, biomarkers all take part in neuroprognosis in cardiac arrest patients, however, these modalities are more expensive or not suitable to repeat in a short time. Optic nerve sheath diameter (ONSD) had been proved to be associated with increased intracranial pressure2 and can be used as one of the prognostic factors in cardiac arrest patients. It is simple, quick and can be measured repeatedly. Carotid duplex and transcranial duplex(TCD) provide rapid, noninvasive, real-time measures of cerebrovascular function. It can be used to assess the vascular territory by measuring blood flow, and to evaluate factors include brain perfusion, plaque morphology, and patency of intracranial collaterals.

Hence, it could act as a crucial role in neuroprognosis in post-arrest patients. In this study, the investigator aimed to analyze the ONSD diameters, ONSD/ETD ratio, carotid duplex and transcaranial duplex parameters in different stages of post-cardiac arrest care, demographic characteristics and resuscitation information with the neurological outcome of post-cardiac arrest patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: December 16, 2023
• Est. primary completion date: December 16, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

. Non-traumatic cardiac arrest adult patients achieving return of spontaneous circulation after resuscitation

Exclusion Criteria:

• traumatic cardiac arrests

• non-traumatic arrest patients without return of spontaneous circulation after resuscitation

Related Conditions & MeSH terms

• Neurologic Dysfunction
• Neurologic Manifestations

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	optic nerve sheath diameter (ONSD)	ONSD measured by ultrasonography during the post-arrest care	7 days
Primary	carotid artery resistance	carotid artery resistance measured by ultrasonography during the post-arrest care	7 days
Primary	middle cerebral artery resistance	middle cerebral artery resistance measured by ultrasonography during the post-arrest care	7 days