Comparing Brain Images Before and After MRI-upgrade - TimFit Upgrade Study

Neuroimaging Clinical Trial

Official title:

Brain Images Before and After Upgrade of the MRI-scanner (Siemens Tim TRIO vs Siemens PRISMA FIT) - The TimFit Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03531580
• Other study ID #: EC/2017/1103
• Status: Completed
• Phase: N/A
• Start date: November 29, 2017
• Est. completion date: June 30, 2018

Study information

• Verified date: November 2021
• Source: University Ghent
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In the Ghent University, an upgrade of the MRI-scanner used for research from Siemens Trio Tim to Siemens Prisma Fit is planned in the near future. As a change of MRI hard- and software might influence brain images, it is necessary to evaluate the images before and after the upgrade.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6
• Est. completion date: June 30, 2018
• Est. primary completion date: June 30, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Healthy volunteer

Exclusion Criteria:

• Protheses or artificial implants, no magnetic or metal parts in the body
• Being pregnant or breastfeeding
• Having claustrophobia

Related Conditions & MeSH terms

• Neuroimaging
• Quality Control

Intervention

Device:
• Magnetic Resonance Imaging
Brain imaging using magnetic resonance imaging, using several MRI sequences: structural imaging (grey matter, using T1-imaging), cerebral perfusion using arterial spin labeling), functional and effective connectivity (using resting-state functional MRI), white matter tracts (using diffusion imaging), white matter lesions (using Fluid-attenuated inversion recovery MRI (FLAIR)) and microbleeds (using Susceptibility weighted imaging (SWI))

Locations

Country	Name	City	State
Belgium	Ghent University	Ghent

Sponsors (1)

Lead Sponsor	Collaborator
University Ghent

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in grey matter volume before versus after MRI-upgrade		7 months, 4 scan sessions of max 1 hour
Primary	Change in cerebral perfusion (ml/100g/min) using Arterial Spin Labeling before versus after MRI-upgrade		7 months, 4 scan sessions of max 1 hour
Primary	Change in arterial transit times before versus after MRI-upgrade		7 months, 4 scan sessions of max 1 hour
Primary	Change in functional connectivity (fc) using Resting State functional MRI before versus after MRI-upgrade		7 months, 4 scan sessions of max 1 hour
Primary	Change in effective connectivity using resting state functional MRI before versus after MRI-upgrade		7 months, 4 scan sessions of max 1 hour
Primary	Change in white matter diffusion before versus after MRI-upgrade		7 months, 4 scan sessions of max 1 hour
Primary	Difference in image quality of FLAIR image before versus after MRI-upgrade		7 months, 4 scan sessions of max 1 hour
Primary	Difference in image quality of SWI image before versus after MRI-upgrade		7 months, 4 scan sessions of max 1 hour