89Zr-Bevacizumab PET/CT Imaging in NF2 Patients

Status Recruiting

Clinical Trial Summary

Bevacizumab can be an effective treatment for individuals with NF2 and improve different nerve functions (like hearing, tinnitus or balance problems) and the quality of life of NF2 patients. However, bevacizumab is not effective in all patients or all tumors, at the cost of moderate toxicity and considerable financial burden. Therefore, this observational study will validate an imaging biomarker method to predict bevacizumab efficacy in order to avoid adverse effects and high costs in non-responders to bevacizumab treatment. Patients will undergo standard-of-care treatment with the sole addition of a pre-treatment 89Zr-Bevacizumab PET/CT-scan. Per standard-of-care bevacizumab therapy is administered every three weeks for six months. To monitor treatment effect, follow-up is performed at 3-month intervals.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05685836
Study type	Observational
Source	Leiden University Medical Center
Contact	Jules PJ Douwes, MD
Phone	715269111
Email	j.p.j.douwes@lumc.nl
Status	Recruiting
Phase
Start date	October 20, 2022
Completion date	December 31, 2024

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