Clinical Trials Logo

Clinical Trial Summary

This project will examine whether individuals can be trained, using real-time feedback about brain function during neuroimaging, to effectively remove thoughts from mind by providing them with a sense of what it feels like to successfully remove a thought.


Clinical Trial Description

On the first day, an anatomical MRI scan will be followed by a 12-min resting state scan, a 30-min item localizer task in which participants view a set of 80 scene stimuli 3 times each, and a 10-min memory test outside the scanner. The brain data from the localizer will be used to identify baseline measures of item-specific brain activity patterns. On 3 subsequent days (within the next 2 weeks), participants will receive neurofeedback training. In each 1-hr session, an anatomical scan will be followed by 8 runs (5 min each) of 20 trials, half with each operation, randomly ordered, and a 10-min behavioral memory test. In the scanner, participants will perform a working memory task in which they encode a scene image and then are instructed to either maintain that image in mind for a few seconds or to suppress that image from mind. At the end of each trial, neurofeedback will be provided to the participant visually to denote their "level of engagement" in the instructed operation on that trial. The neurofeedback is derived from the MRI classifier fit for the instructed operation (maintain or suppress) from a working memory operation classifier that is pre-trained on prior data. Participants (N=40) will be randomly assigned to either the positive or negative valence condition. They will encounter stimuli from their assigned valence only during the neuroimaging task, but from both valences during the behavioral tests, so that the investigators can evaluate whether any learning generalizes across emotional valence. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06460207
Study type Interventional
Source University of Texas at Austin
Contact Caleb Jerininc-Brodeur, B.S.
Phone (415) 320-3457?
Email cjerinic@utexas.edu
Status Not yet recruiting
Phase N/A
Start date September 2024
Completion date December 2025

See also
  Status Clinical Trial Phase
Completed NCT05980286 - Impact of Musical Improvisation Training on Cognitive Function in Older Adults N/A
Recruiting NCT06110858 - Efficacy of Tinkering Activities in Individuals With Subjective Cognitive Decline N/A
Recruiting NCT05929287 - Comparing Personalized and Adaptive Cognitive Training Methods Following Stroke N/A
Enrolling by invitation NCT05355870 - Cognitive Training RCT for Older Chinese Americans N/A
Suspended NCT05773430 - The Targeted Neurocognitive Training (TNT) Study N/A
Not yet recruiting NCT05472194 - Promoting Inclusive Education Through Executive Functions N/A
Recruiting NCT05598047 - Executive Functioning Training Study Phase 2
Withdrawn NCT03950648 - Spatial Cognitive Training for Chronic Vestibular Disorders N/A
Completed NCT03419052 - MINDSpeed Food and Brain Training RCT N/A
Recruiting NCT05358145 - The Training Effects of Tinkering Activities on Cognitive Flexibility in Older Adults From Communities N/A
Completed NCT01616797 - A Novel Neurobehavioral Intervention for Emotion Regulation in Anxiety and Depression Across the Lifespan N/A
Completed NCT03790696 - Novel Anxiety Treatment N/A
Completed NCT04615169 - Multi-component Cognitive Intervention for Older Adults With Mixed Cognitive Abilities N/A
Completed NCT05558839 - The Effect of Exercise and Cognitive Training on Community-dwelling Older Adults With Dementia. N/A
Recruiting NCT05198726 - Speed of Processing (SoP) Training Plus α-tACS N/A