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Perinatal Covid-19 Infection, NO Pathway, and Minipuberty — miniNO-COVID  

Neurodevelopmental Disorders Clinical Trial

Official title:
Exploratory Multicenter Observational Study to Assess the Outcome of Infants With Perinatal SARS-COV-2 Infection and Its Link With the NO Pathway: the Minipuberty Hypothesis

Clinical Trial Summary

Some evidence exists that SARS-COV-2 may infect pituitary axis, and therefore may alter hypothalamic function. Whether perinatal COVID-19 is associated with alterations in the maturation of the Hypothalamic-Pituitary-Gonadal (HPG) axis, and specifically with its transient activation occurring during infancy, namely minipuberty, is a major concern. Among the various pathogenic features related to COVID-19, altered minipuberty could be a key factor underlying many multimorbidities later in life, suggesting that they could involve a common causative mechanism that occurs within this short and critical period of time following birth. Altered minipuberty together with NO deficiency seem to be key factors underlying many of these multimorbidities, suggesting that they involve a common causative mechanism that occurs within this short and critical period of time following birth

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04952870
Study type Observational
Source University Hospital, Lille
Contact Laurent STORME, MD,PhD
Phone 0320445962
Email laurent.storme@chru-lille.fr
Status Recruiting
Phase
Start date November 3, 2022
Completion date November 2026
View Details
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