Clinical Trials Logo
  1. Home
  2. Neurodevelopmental Disorder
  3. NCT02557191

Biomarkers, Neurodevelopment and Preterm Infants

Preterm Clinical Trial

Official title:
Biomarkers to Predict Neurodevelopmental Outcomes in Very Preterm Infants

Clinical Trial Summary

Approximately 2% of neonates in the US are born very preterm. Preterm births are associated with impaired cognitive, language and motor function, and increased risk for autism spectrum disorders. Epidemiological studies indicate a dose-response relationship between gestational age at delivery and cognitive impairments, with the most immature of newborns being the most susceptible to developmental delays. Sensitive and reproducible biomarkers of long-term neurocognitive impairments are currently lacking. The investigators seek to identify epigenetic markers that mediate the relationship between adverse prematurity-related exposures and neurocognitive impairments. The overarching hypothesis of this proposal is that DNA methylation profiles of CD34+ hematopoetic progenitor and stem cells from very preterm infants can be used as a risk-stratifying biomarker for predicting neurocognitive impairment in childhood.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02557191
Study type Observational [Patient Registry]
Source Montefiore Medical Center
Contact
Status Terminated
Phase
Start date April 2015
Completion date December 2018
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06105333 - Fidgety Movements of Preterm Neonates Included in COSGOD III
Recruiting NCT05729321 - Lock sOlutiOnS for Epicutaneo-caval Catheters in Neonates: a "LOOSEN" Pilot Study
Completed NCT05509621 - The Effect of Positions on Physiological Parameters of Preterm Neonates Receiving Mechanical Ventilation N/A
Enrolling by invitation NCT06116747 - The SUPPORTED Study - First-time Fathers of Preterm Infants. N/A
Active, not recruiting NCT01443195 - Iron Metabolism in Small Pre Term Newborns N/A
Withdrawn NCT05053269 - Body Weight Growth After Birth and Bronchopulmonary Dysplasia
Not yet recruiting NCT06118801 - The Effect of Probiotics Added to the Mother's Diet on Preterm Babies N/A
Completed NCT05453734 - The Effect of Progressive Muscle Relaxation Exercises N/A
Recruiting NCT05230199 - Sensory Optimization of the Hospital Environment N/A
Completed NCT06204146 - The Effect of Massage on Growth And Stress And Stress ,Department of Nursing, N/A
Recruiting NCT05687500 - Oral Glibenclamide in Preterm Infants With Hyperglycaemia (GALOP) Phase 2
Completed NCT05830955 - The Effect of Lullaby and Breastmilk Smell on Preterm Newborns N/A
Active, not recruiting NCT06246032 - Impact of Modified Feeding Protocol on Neonatal Outcomes N/A
Completed NCT05359809 - Peripheral Intravenous Central Catheter Intervention in Preterm Infants N/A
Not yet recruiting NCT05331235 - Blood Transfusions in Preterm Infants
Not yet recruiting NCT05434364 - Comparison Three Methods on Endotracheal Aspiration in Preterm Infants N/A
Completed NCT05805254 - Neurofunctional Study of Preterm Infants' Brain Activity
Completed NCT01776281 - Effects of Kangaroo Mother Care Among Low Birth Weight (LBW) and Preterm Infants Phase 2
Completed NCT05978674 - The Effect of Rocking Bed on Preterm Newborns N/A
Completed NCT05261503 - Investigation of the Effectiveness of Environmental Enrichment-Based Intervention in Preterm Infants N/A