Amyotrophic Lateral Sclerosis Clinical Trial
Official title:
ALS Tissue Donation Program
Despite significant progress in the identification of mechanisms involved in motor neuron
degeneration in Amyotrophic Lateral Sclerosis (ALS) and other motor system diseases, the
actual pathogenesis and cause of these diseases remains unknown. Effective treatment of
these diseases are dependent on the elucidation of their causes. The availability of
diseased and control human tissues will be a critical resource for this research progress. .
Samples of serum, spinal fluid, and urine from patients with motor system diseases can be
used to study biochemical and genetic differences compared to tissues of neurologic disease
controls and normal controls. Furthermore, the availability of autopsied CNS, PNS, as well
as other tissues from patients with ALS or suspected ALS are useful for current and future
research studies into the disease. Therefore, we propose to institute a Tissue Bank
containing blood, urine, and cerebrospinal fluid donated from not only ALS and other motor
neuron disease patients, but also those with other neurologic diseases and normals whose
tissue can be used as controls. In addition there will be an autopsy band for post-mortem
specimens of ALS and other motor neuron disease patients. Each specimen, whether from a
living patient or autopsy will be de-identified and accompanied by a standard set of
clinical information collected from the medical records in order that each specimen is
characterized with the relevant clinical information to maximize the usefulness of the
specimens.
Once established, this tissue bank will provide a resource in which a large number of
samples will be readily available and expedite research by circumventing the delays in
collecting specimens prospectively. These specimens will be used for research in the ALS
Center of Hope at Drexel University College of Medicine and shared with any outside
investigator with a valid IRB approved protocol.
Despite significant progress in the identification of mechanisms involved in motor neuron
degeneration in Amyotrophic Lateral Sclerosis (ALS) and other motor system diseases, the
actual pathogenesis and cause of these diseases remains unknown. Effective treatment of
these diseases are dependent on the elucidation of their causes. The availability of
diseased and control human tissues will be a critical resource for this research progress. .
Samples of serum, spinal fluid, and urine from patients with motor system diseases can be
used to study biochemical and genetic differences compared to tissues of neurologic disease
controls and normal controls. Furthermore, the availability of autopsied CNS, PNS, as well
as other tissues from patients with ALS or suspected ALS are useful for current and future
research studies into the disease. Therefore, we propose to institute a Tissue Bank
containing blood, urine, and cerebrospinal fluid donated from not only ALS and other motor
neuron disease patients, but also those with other neurologic diseases and normals whose
tissue can be used as controls. In addition there will be an autopsy band for post-mortem
specimens of ALS and other motor neuron disease patients. Each specimen, whether from a
living patient or autopsy will be de-identified and accompanied by a standard set of
clinical information collected from the medical records in order that each specimen is
characterized with the relevant clinical information to maximize the usefulness of the
specimens.
Once established, this tissue bank will provide a resource in which a large number of
samples will be readily available and expedite research by circumventing the delays in
collecting specimens prospectively. These specimens will be used for research in the ALS
Center of Hope at Drexel University College of Medicine and shared with any outside
investigator with a valid IRB approved protocol.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT04428775 -
A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease
|
Phase 2 | |
Recruiting |
NCT04998305 -
TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps
|
Phase 1/Phase 2 | |
Recruiting |
NCT05951556 -
Telehealth Implementation of Brain-Computer Interface
|
N/A | |
Terminated |
NCT04579666 -
MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)
|
Phase 2 | |
Recruiting |
NCT04082832 -
CuATSM Compared With Placebo for Treatment of ALS/MND
|
Phase 2/Phase 3 | |
Completed |
NCT01925196 -
Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation
|
||
Completed |
NCT02496767 -
Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year
|
Phase 3 | |
Recruiting |
NCT04816227 -
Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments
|
||
Active, not recruiting |
NCT04494256 -
A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With Amyotrophic Lateral Sclerosis (ALS) and Participants With the ALS Ataxin-2 (ATXN2) Genetic Mutation
|
Phase 1/Phase 2 | |
Completed |
NCT03706391 -
Study of ALS Reversals 4: LifeTime Exposures
|
||
Recruiting |
NCT04882904 -
Continuous Measurement of Activity in Patients With Muscle Pathology and in Control Subjects. ActiSLA Part.
|
N/A | |
Completed |
NCT04557410 -
Open Label Study: Treatment of ALS Fatigue With PolyMVA
|
Phase 1 | |
Active, not recruiting |
NCT04948645 -
A Phase 1 Study to Investigate the Safety and Pharmacokinetics of ABBV-CLS-7262 in Patients With Amyotrophic Lateral Sclerosis
|
Phase 1 | |
Not yet recruiting |
NCT04089696 -
Validation of the "ExSpiron©" in Patients With ALS
|
N/A | |
Not yet recruiting |
NCT06450691 -
Modeling Amyotrophic Lateral Sclerosis With Fibroblasts
|
N/A | |
Not yet recruiting |
NCT04220190 -
RAPA-501 Therapy for ALS
|
Phase 2/Phase 3 | |
Not yet recruiting |
NCT05860244 -
Effect of Salbutamol on Walking Capacity in Ambulatory ALS Patients
|
Phase 2 | |
Recruiting |
NCT02917681 -
Study of Two Intrathecal Doses of Autologous Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT03067857 -
Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron Disease
|
Phase 1/Phase 2 | |
Recruiting |
NCT02874209 -
Noninvasive Assessment of Neuronal Damage by MRI Sodium ( 23Na ) in Amyotrophic Lateral Sclerosis
|
N/A |