Neurocognitive Dysfunction Clinical Trial
Official title:
Validation of a German Translation and Cultural Adaptation of the Addenbrooke's Cognitive Examination III
The aim of the entire project was to perform a translation and cultural adaptation of the
Addenbrooke's Cognitive Examination - III (ACE-III), adhering to the Translation and Cultural
Adaptation of Patient Reported Outcomes Measures—Principles of Good Practice, in order to
make it available to German clinicians.
Part of the translation process is the cognitive debriefing which will be performed as a
survey which rates the applicability of every single item as well as of the entire
Addenbrooke's Cognitive Examination - III tool.
The recent demographic developments have drastically increased the importance of developing
applicable approaches to the diagnostics of dementia and the general evaluation of cognitive
function. Many different tests were developed to thoroughly evaluate neurocognitive function.
The Addenbrooke's Cognitive Examination, developed in 2000, was one such tests and has served
as an open source neurocognitive examination tool ever since. The current version is the
Addenbrooke's Cognitive Examination III (ACE-III). The aim was to develop a tool that would
be able to identify dementia in its early stages and also to differentiate between the
different types of dementia.
In order to achieve reliable results, cognitive tests should be conducted in a familiar
language and draw from the cultural background a participant is familiar with. The ACE-III
and all its predecessors were developed in English and for an English-speaking cultural
background, not directly applicable to the typical German patient. This made it necessary to
perform not only a verbatim translation of test contents, but also to appropriately adapt the
test content to reflect the cultural background of the typical German patient. The
International Society For Pharmacoeconomics and Outcomes Research (ISPOR) - Task Force for
Translation and Cultural Adaptation has developed the "Translation and Cultural Adaptation of
Patient Reported Outcomes Measures—Principles of Good Practice", to ensure a consistent and
rigorous methodology in the process of translating and adapting patient-reported outcomes
measures.
The Principles of Good Practice consist of ten steps:
1. Preparation
2. Forward Translation
3. Reconciliation
4. Back Translation
5. Back Translation Review
6. Harmonization
7. Cognitive Debriefing
8. Review of Cognitive Debriefing Results and Finalization
9. Proofreading
10. Final Report
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