Neurocognitive Dysfunction Clinical Trial
Official title:
Validation of a German Translation and Cultural Adaptation of the Addenbrooke's Cognitive Examination III
The aim of the entire project was to perform a translation and cultural adaptation of the
Addenbrooke's Cognitive Examination - III (ACE-III), adhering to the Translation and Cultural
Adaptation of Patient Reported Outcomes Measures—Principles of Good Practice, in order to
make it available to German clinicians.
Part of the translation process is the cognitive debriefing which will be performed as a
survey which rates the applicability of every single item as well as of the entire
Addenbrooke's Cognitive Examination - III tool.
The recent demographic developments have drastically increased the importance of developing
applicable approaches to the diagnostics of dementia and the general evaluation of cognitive
function. Many different tests were developed to thoroughly evaluate neurocognitive function.
The Addenbrooke's Cognitive Examination, developed in 2000, was one such tests and has served
as an open source neurocognitive examination tool ever since. The current version is the
Addenbrooke's Cognitive Examination III (ACE-III). The aim was to develop a tool that would
be able to identify dementia in its early stages and also to differentiate between the
different types of dementia.
In order to achieve reliable results, cognitive tests should be conducted in a familiar
language and draw from the cultural background a participant is familiar with. The ACE-III
and all its predecessors were developed in English and for an English-speaking cultural
background, not directly applicable to the typical German patient. This made it necessary to
perform not only a verbatim translation of test contents, but also to appropriately adapt the
test content to reflect the cultural background of the typical German patient. The
International Society For Pharmacoeconomics and Outcomes Research (ISPOR) - Task Force for
Translation and Cultural Adaptation has developed the "Translation and Cultural Adaptation of
Patient Reported Outcomes Measures—Principles of Good Practice", to ensure a consistent and
rigorous methodology in the process of translating and adapting patient-reported outcomes
measures.
The Principles of Good Practice consist of ten steps:
1. Preparation
2. Forward Translation
3. Reconciliation
4. Back Translation
5. Back Translation Review
6. Harmonization
7. Cognitive Debriefing
8. Review of Cognitive Debriefing Results and Finalization
9. Proofreading
10. Final Report
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04005456 -
Personalized Lifestyle Intervention for Improving Functional Health Outcomes Using N-of-1 Tent-Umbrella-Bucket Design
|
N/A | |
Enrolling by invitation |
NCT06227962 -
Cognitive Functioning and Health Related Quality of Life in Retinoblastoma Survivors
|
||
Completed |
NCT04038788 -
Add-on HD Hf-tRNS Over Bilateral DLPFC for Treating Patients With Schizophrenia
|
N/A | |
Withdrawn |
NCT01186289 -
Statin Therapy To Limit Cognitive Dysfunction After Cardiac Surgery
|
N/A | |
Recruiting |
NCT05077748 -
An 18-year Follow-up Study on OSA in a Population-based Cohort
|
||
Recruiting |
NCT03606421 -
CBF and NCF Changes With Brain Radiation
|
||
Recruiting |
NCT03709199 -
Long Term Follow up of Children Enrolled in the REDvent Study
|
||
Recruiting |
NCT04458207 -
Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study
|
N/A | |
Recruiting |
NCT05363332 -
Impact and Sequelae of High Ventilatory Drive in Critically Ill COVID-19 Patients
|
||
Recruiting |
NCT03886675 -
Intervention With Cerebral Embolic Protection in TEVAR: Gaseous Protection
|
N/A | |
Enrolling by invitation |
NCT04373525 -
Prospective Evaluation on Cognitive Function and Its Associated Genetic Vulnerability in Cannabis Users
|
||
Enrolling by invitation |
NCT04881266 -
Long-Term Functional, Quality-of-Life, Neuropsychological and Cognitive Outcomes in COVID-19 Critical Illness Survivors
|
||
Completed |
NCT03795454 -
Can Singing Kangaroo Improve Outcome of Preterm Infants
|
N/A | |
Recruiting |
NCT05019300 -
Long-term Neurocognitive and Psychiatric Consequences in Severe COVID-19 Survivors.
|
||
Not yet recruiting |
NCT05245903 -
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
|
||
Terminated |
NCT03163277 -
Using Less Neurotoxic Drugs in Patients With HAND (MARAND-X)
|
Phase 4 | |
Not yet recruiting |
NCT06224088 -
Neuro-cognitive Function 1 Year Post ICU Discharge Among VV ECMO Survivors
|
||
Not yet recruiting |
NCT06413173 -
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
|
N/A | |
Terminated |
NCT03863639 -
Changes in fMRI and Neurocognitive Function in Women With Pre-eclampsia
|
||
Enrolling by invitation |
NCT03567304 -
Neurocognitive Function Improvement After Switching From Efavirenz to Rilpivirine
|
Phase 4 |