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Clinical Trial Summary

The survival rate of recurrent and refractory pediatric neuroblastoma is low and the prognosis is poor. Apatinib mesylate is a highly selective small-molecule vasoendothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor. Apatinib mesylate has been shown to be safe and effective in recurrent or refractory pediatric neuroblastoma in Sun Yat-sen University Cancer Center. Apatinib mesylate combined with IT regimen is expected to further improve the efficacy and survival rate of recurrent or refractory pediatric neuroblastoma.

Clinical Trial Description

The enrolled patients diagnosed with recurrent or refractory pediatric neuroblastoma received apatinib combined with IT regimen chemotherapy, the treatment including combination therapy phase and monotherapy maintenance phase. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05027386
Study type Interventional
Source Sun Yat-sen University
Contact Yizhuo Zhang
Phone 020-87342460
Email [email protected]
Status Not yet recruiting
Phase Phase 2
Start date August 26, 2021
Completion date August 30, 2023

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